{"id":"W2969094441","doi":"10.1021/acsinfecdis.9b00232","title":"Preserving the Efficacy of Glycopeptide Antibiotics during Nanoencapsulation in Liposomes","year":2019,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University; McMaster University","keywords":"Teicoplanin; Liposome; Antibiotics; Vancomycin; Sonication; Glycopeptide; Glycopeptide antibiotic; Staphylococcus aureus; Microbiology; Potency; Chemistry; Chromatography; Bacteria; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004298446,0.0003568932,0.0002397925,0.0001422798,0.0001196269,0.0004146607,0.0001722666,0.0002759971,0.0002865343],"category_scores_gemma":[0.0005180664,0.0001556813,0.0002267492,0.0001154796,0.0002961745,0.0005565632,0.0002818795,0.0004153378,0.0001616503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002653492,"about_ca_system_score_gemma":0.0002119545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005051502,"about_ca_topic_score_gemma":0.0005123487,"domain_scores_codex":[0.9997787,0.0000414617,0.00002598502,0.00005779088,0.00004659638,0.00004944035],"domain_scores_gemma":[0.9997594,0.00007743707,0.0000660837,0.00003352762,0.00004413103,0.00001958291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003969253,0.000005917416,0.0000598308,0.00002050984,0.000002169501,0.00001216632,0.00001994543,0.0000643469,0.9991521,0.0000285136,0.000005381506,0.000589566],"study_design_scores_gemma":[0.000002718061,0.00005541311,0.0003189638,0.000002667208,0.000003885717,0.00001140897,0.000006475092,0.0002483391,0.9991537,0.000006940806,0.0001873399,0.000002056184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958498,0.0006170892,0.00302758,0.00002831874,0.00001104083,0.00003561145,0.00006557534,0.00002891346,0.0003360701],"genre_scores_gemma":[0.9956675,0.0004620832,0.003135001,0.00002305941,0.000004413419,0.00003402176,0.00007377215,0.00002522767,0.0005749002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005051502,"threshold_uncertainty_score":0.002273262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003922195416387508,"score_gpt":0.2190614979584048,"score_spread":0.2151393025420173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}