{"id":"W2969138527","doi":"10.1002/pro.3708","title":"Identification of the active site residues in ATP‐citrate lyase's carboxy‐terminal portion","year":2019,"lang":"en","type":"article","venue":"Protein Science","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Argonne National Laboratory; Western Economic Diversification Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Research Council Canada; Canada Foundation for Innovation; University of Saskatchewan","keywords":"ATP citrate lyase; Citrate synthase; Lyase; Citric acid cycle; Biochemistry; Active site; Tricarboxylic acid; Chemistry; Acetyl-CoA; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000992654,0.0000740422,0.00009548933,0.0001010732,0.000108009,0.00005996899,0.0003684471,0.00003675089,0.00007416898],"category_scores_gemma":[0.0001463555,0.00005111099,0.00002657382,0.0007064797,0.0003248287,0.0006416559,0.00008055131,0.00008298571,0.00005974609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006958106,"about_ca_system_score_gemma":0.0001417681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002521165,"about_ca_topic_score_gemma":0.0001047424,"domain_scores_codex":[0.9986714,0.00005825028,0.0002659563,0.0003233678,0.0004891747,0.0001918997],"domain_scores_gemma":[0.9991932,0.00001440696,0.0002685304,0.0003681376,0.0001283587,0.00002734929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002748054,0.000009199256,0.00496753,0.00001546148,2.823931e-7,4.288374e-7,0.0006363568,0.00006879753,0.9932002,0.0005069774,0.000001853211,0.0005653842],"study_design_scores_gemma":[0.00007684921,0.0000271069,0.2567043,0.00003186797,0.000001957354,0.000002410859,0.00007844928,0.0001756604,0.7419733,0.0008623825,0.00001675827,0.00004898082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980832,0.00001594034,0.0000818997,0.0001203905,0.0003910251,0.0005039166,0.000007229844,0.00001591699,0.0007804692],"genre_scores_gemma":[0.999442,9.663485e-7,0.0001424591,0.00002755315,0.00002907578,0.00002456861,7.168294e-7,0.000003775185,0.0003288399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2517368,"threshold_uncertainty_score":0.2084246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007304495429080617,"score_gpt":0.2417650770375621,"score_spread":0.2344605816084815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}