{"id":"W2969238338","doi":"10.1186/s13059-019-1776-2","title":"Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation","year":2019,"lang":"en","type":"article","venue":"Genome biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre Hospitalier de l’Université de Montréal; McGill University Health Centre","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences; Biotechnology and Biological Sciences Research Council; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; University of California, Davis; Directorate for Biological Sciences; National Institutes of Health; Akademie Věd České Republiky; Indiana Clinical and Translational Sciences Institute; Ministerstvo Školství, Mládeže a Tělovýchovy; Ministry of Education, Culture, Sports, Science and Technology; McGill University; McGill University Health Centre; National Cancer Institute; British Heart Foundation; National Center for Advancing Translational Sciences; Wellcome Trust; Japan Agency for Medical Research and Development; Canadian Institutes of Health Research; Royal Society; Wellcome","keywords":"CRISPR; Biology; Cas9; Conditional gene knockout; Genome editing; Genetics; Homologous recombination; Computational biology; Allele; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.06787476,0.001593056,0.00141453,0.002990703,0.001330988,0.002618695,0.002339185,0.00152016,0.001116102],"category_scores_gemma":[0.07965269,0.0006108426,0.002440317,0.002156526,0.001196549,0.001368482,0.002657737,0.001314035,0.001075931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001360572,"about_ca_system_score_gemma":0.001260769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002311555,"about_ca_topic_score_gemma":0.002504934,"domain_scores_codex":[0.9453961,0.01781419,0.006437137,0.01152796,0.01778445,0.001040347],"domain_scores_gemma":[0.8480282,0.05958514,0.01391036,0.03653803,0.03970534,0.002233005],"domain_codex":null,"domain_gemma":"reproducibility","domain_candidate":"reproducibility","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007088607,0.002735128,0.4332279,0.002799774,0.009175781,0.000509719,0.001247381,0.04069799,0.1386455,0.001872114,0.01677561,0.3452245],"study_design_scores_gemma":[0.000401062,0.006965752,0.5134926,0.000584773,0.003791583,0.002040309,0.0007574239,0.1005778,0.3334381,0.002977504,0.03429566,0.0006773989],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7994721,0.006614608,0.170485,0.0005889011,0.0006272142,0.001592479,0.01284448,0.003245669,0.004529624],"genre_scores_gemma":[0.8656343,0.0009713675,0.09929439,0.0003165623,0.0001425236,0.00159737,0.02859822,0.001684177,0.001761135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9321252,"threshold_uncertainty_score":0.3589603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06423970125261735,"score_gpt":0.4498523355932214,"score_spread":0.3856126343406041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}