{"id":"W2969254664","doi":"10.1093/molbev/msz192","title":"Direct Evidence of an Increasing Mutational Load in Humans","year":2019,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Biology; Allele; Genetics; Balancing selection; Genetic drift; Evolutionary biology; Allele frequency; Population; Selection (genetic algorithm); Disease; Genetic variation; Demography; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005519623,0.0001845444,0.000384889,0.001184146,0.0004696785,0.0009634091,0.0002890402,0.0008882496,0.003437148],"category_scores_gemma":[0.002429192,0.0002473519,0.000202646,0.001487551,0.001145723,0.0006719925,0.0007105715,0.0006734305,0.0003996683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002550324,"about_ca_system_score_gemma":0.0002030355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001323766,"about_ca_topic_score_gemma":0.001592359,"domain_scores_codex":[0.9993215,0.0001146062,0.00004303614,0.0003407739,0.0001329551,0.00004716859],"domain_scores_gemma":[0.9987727,0.0003157144,0.000421758,0.0002020233,0.0001592036,0.0001286182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007151463,0.00007564577,0.8085696,0.0004406477,0.0008181658,0.001199016,0.002483173,0.001211758,0.1047308,0.00460781,0.001569269,0.07357901],"study_design_scores_gemma":[0.00001007567,0.00008074773,0.9900659,0.0000279747,0.00005488476,0.0014717,0.0002734493,0.0003130645,0.001599858,0.002354404,0.003728929,0.00001896343],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911522,0.002782271,0.001298209,0.0005759639,0.00002873766,0.000006017787,0.000552011,0.00005150014,0.003553184],"genre_scores_gemma":[0.9967894,0.001282804,0.0006852247,0.0002722855,0.00008372947,0.000004967632,0.0003024891,0.00001510134,0.0005638927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003437148,"threshold_uncertainty_score":0.01149845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006001039486981477,"score_gpt":0.2802218495751305,"score_spread":0.274220810088149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}