{"id":"W2969279681","doi":"10.15252/embr.201947911","title":"Iron overload inhibits late stage autophagic flux leading to insulin resistance","year":2019,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Metropolitan University; University of Ottawa; York University","funders":"Institute of Nutrition, Metabolism and Diabetes; Government of Canada","keywords":"Autophagy; Insulin resistance; Flux (metallurgy); Cell biology; Mitochondrion; Biology; Insulin; Chemistry; Endocrinology; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002897796,0.0004451711,0.0007231368,0.000307992,0.000286783,0.000461664,0.0002921099,0.00064112,0.002497026],"category_scores_gemma":[0.000285507,0.000242574,0.0004178542,0.0001138035,0.0003460322,0.0003956992,0.0003406183,0.001157306,0.0005403741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002821212,"about_ca_system_score_gemma":0.000341813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004248836,"about_ca_topic_score_gemma":0.0006288232,"domain_scores_codex":[0.9998348,0.00003302212,0.00001717167,0.00003039278,0.00002132518,0.00006333861],"domain_scores_gemma":[0.9998084,0.00003615492,0.00002878517,0.00002819577,0.00002346294,0.00007499566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008943622,0.0004272948,0.0002387027,0.0001353315,0.00002618424,0.0001688739,0.000034819,0.00008090305,0.9829029,0.0003253125,0.0005502782,0.006165719],"study_design_scores_gemma":[0.0006425135,0.002462003,0.006694969,0.00003929946,0.00006328199,0.0004411027,0.00008856566,0.001495135,0.9814197,0.0004960057,0.006138033,0.00001935578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868677,0.003492358,0.004661761,0.0007274356,0.0004115126,0.00006686745,0.0003833201,0.0003533039,0.003035759],"genre_scores_gemma":[0.9929663,0.0009178142,0.001966062,0.0002110471,0.00008326647,0.00005402598,0.0002955537,0.0000550739,0.003450979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002497026,"threshold_uncertainty_score":0.008353353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009407955197009045,"score_gpt":0.2611548865795439,"score_spread":0.2517469313825349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}