{"id":"W2969310179","doi":"10.1001/jamaneurol.2019.2478","title":"Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis","year":2019,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Sanofi Genzyme; Chugai Pharmaceutical; Amsterdam Neuroscience; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Medizinische Universität Graz; Berlin Institute of Health; Bundesministerium für Bildung und Forschung; Università degli Studi di Verona; Alexion Pharmaceuticals; University of Toronto; Vrije Universiteit Amsterdam; Sanofi; Humboldt-Universität zu Berlin; Bayer HealthCare; European Commission; Amsterdam University Medical Centers; Biogen; Celgene; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Freie Universität Berlin; Karl-Franzens-Universität Graz; Eli Lilly and Company; Uniwersytet Mikolaja Kopernika w Toruniu; Arthur Arnstein Stiftung; Teva Pharmaceutical Industries; Università degli Studi di Siena","keywords":"Medicine; Multiple sclerosis; Neuroimaging; Magnetic resonance imaging; Imaging biomarker; Radiology; Biomarker; Observational study; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00434745,0.000385732,0.0005962879,0.00116811,0.0003072307,0.0007051727,0.0004474803,0.0006305388,0.0007754708],"category_scores_gemma":[0.01108391,0.0001695591,0.0002604038,0.001169265,0.0004978756,0.0008344555,0.0004040254,0.0003623019,0.0001353498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002119306,"about_ca_system_score_gemma":0.0004400554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002943863,"about_ca_topic_score_gemma":0.0006008808,"domain_scores_codex":[0.9978536,0.001147203,0.00036269,0.0002251227,0.0003193347,0.00009200778],"domain_scores_gemma":[0.9918633,0.002291992,0.004341369,0.0003303868,0.0007662192,0.0004068488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000707968,0.00009335904,0.992743,0.00008134879,0.00009111787,0.0001270108,0.00006306756,0.00005929103,0.001080828,0.00002678572,0.0001011154,0.004825175],"study_design_scores_gemma":[0.00007891656,0.001356143,0.9934377,0.00007185852,0.0001513086,0.001821912,0.0001847886,0.0009149309,0.001414397,0.0001725275,0.0003793243,0.00001626081],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977289,0.001118412,0.0004619152,0.00007674212,0.00001686917,0.0000534228,0.0001394809,0.000007185599,0.0003971453],"genre_scores_gemma":[0.9987419,0.0001715429,0.0008655795,0.00002887416,0.00002539386,0.0000335648,0.00008296886,0.000001631831,0.00004857323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00434745,"threshold_uncertainty_score":0.02299178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08356473709973958,"score_gpt":0.3181338420705178,"score_spread":0.2345691049707782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}