{"id":"W2969359780","doi":"10.1093/biolre/ioz168","title":"Resiliency of equid H19 imprint to somatic cell reprogramming by oocyte nuclear transfer and genetically induced pluripotency†","year":2019,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Reprogramming; Somatic cell nuclear transfer; Biology; Genomic imprinting; Imprinting (psychology); Epigenetics; Induced pluripotent stem cell; DNA methylation; Somatic cell; Genetics; Embryonic stem cell; Differentially methylated regions; Cell biology; Methylation; Embryo; Gene; Gene expression; Blastocyst; Embryogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930143,0.0001703129,0.0001448844,0.0002534839,0.0001786155,0.0002381899,0.0002050872,0.0002323222,0.002020998],"category_scores_gemma":[0.0002006103,0.00008138713,0.0001237734,0.000103247,0.0002786017,0.0002153607,0.0002777446,0.0002541215,0.0002433968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002008551,"about_ca_system_score_gemma":0.000138248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004928126,"about_ca_topic_score_gemma":0.0007835948,"domain_scores_codex":[0.9998486,0.00001832702,0.0000152182,0.00004976146,0.00004356977,0.00002441948],"domain_scores_gemma":[0.9998996,0.00002468193,0.00002945283,0.00001803173,0.00001269129,0.00001552626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003726502,0.000007592424,0.0009895959,0.00001965874,0.000004682243,0.00009915585,0.00004452993,0.00005069937,0.9962335,0.000139014,0.00001393712,0.002360389],"study_design_scores_gemma":[0.000005389502,0.0002358486,0.04093114,0.000007780647,0.00002017356,0.001042926,0.0001320897,0.0006743805,0.951332,0.0001535681,0.005456911,0.000007730309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911431,0.001059403,0.00477278,0.00005180576,0.00001551386,0.00003805816,0.000318627,0.00004634994,0.002554478],"genre_scores_gemma":[0.9945624,0.000459791,0.00140593,0.00003355555,0.000004616923,0.0000355801,0.0005586988,0.00002301473,0.00291642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002020998,"threshold_uncertainty_score":0.006760895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006901241267795797,"score_gpt":0.2263980505622915,"score_spread":0.2194968092944957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}