{"id":"W2969359780","doi":"10.1093/biolre/ioz168","title":"Resiliency of equid H19 imprint to somatic cell reprogramming by oocyte nuclear transfer and genetically induced pluripotency†","year":2019,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Reprogramming; Somatic cell nuclear transfer; Biology; Genomic imprinting; Imprinting (psychology); Epigenetics; Induced pluripotent stem cell; DNA methylation; Somatic cell; Genetics; Embryonic stem cell; Differentially methylated regions; Cell biology; Methylation; Embryo; Gene; Gene expression; Blastocyst; Embryogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003491761,0.0001321047,0.0002377756,0.00005484862,0.0000304449,0.000005210104,0.0001360561,0.0001758408,0.00002083979],"category_scores_gemma":[0.0001003788,0.000126144,0.00006574063,0.00008807339,0.00008176106,0.000003176012,0.0001179232,0.0000655535,0.000007018667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006662522,"about_ca_system_score_gemma":0.00002831722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005561769,"about_ca_topic_score_gemma":0.000001333096,"domain_scores_codex":[0.9985974,0.00006136687,0.0003791963,0.0006723246,0.0000738879,0.0002158511],"domain_scores_gemma":[0.9991371,0.000006649116,0.00009515421,0.0006046544,0.00009551652,0.00006092954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004233198,0.00005240865,0.006734207,0.00008053963,0.00002194996,7.013725e-8,0.0001117928,0.000008044556,0.9502374,0.00002635962,0.00002041903,0.04266447],"study_design_scores_gemma":[0.0003577974,0.001719759,0.0237179,0.00001832664,0.00001650221,0.00002380745,0.0001466532,0.00001852869,0.9687963,0.00005186116,0.00498571,0.0001468629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966312,0.001617601,0.0007875807,0.0001509921,0.0002001923,0.0003778779,0.000003578006,0.000009701745,0.0002212864],"genre_scores_gemma":[0.9950539,0.0002813448,0.004407972,0.00001852956,0.00005706296,0.000007235572,0.00001221217,0.00001839952,0.0001433555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04251761,"threshold_uncertainty_score":0.5144004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006901241267795797,"score_gpt":0.2263980505622915,"score_spread":0.2194968092944957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}