{"id":"W2969421703","doi":"10.1002/pros.23895","title":"A three‐gene DNA methylation biomarker accurately classifies early stage prostate cancer","year":2019,"lang":"en","type":"article","venue":"The Prostate","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Ontario Institute for Cancer Research; McGill University Health Centre; University of Toronto; SickKids Foundation; Hospital for Sick Children; Bank of Canada; Ted Rogers Centre for Heart Research; London Health Sciences Centre; Queen's University","funders":"Southeastern Ontario Academic Medical Organization; Canadian Institutes of Health Research; Terry Fox Foundation; Prostate Cancer Canada; Movember Foundation","keywords":"GSTP1; Prostate cancer; DNA methylation; Biomarker; Methylation; Prostate; Oncology; Medicine; Biomarker discovery; Logistic regression; Cancer; Cancer biomarkers; Stage (stratigraphy); Biology; Internal medicine; Gene; Genotype; Genetics; Proteomics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001074582,0.0004510638,0.0004949065,0.0009441543,0.0001894322,0.0005702486,0.0003196132,0.0005174616,0.000750511],"category_scores_gemma":[0.001859586,0.0001740127,0.000406708,0.0005858344,0.000236987,0.000248271,0.0003660952,0.000476766,0.0002893702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004875754,"about_ca_system_score_gemma":0.0006399726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001318942,"about_ca_topic_score_gemma":0.00329282,"domain_scores_codex":[0.9996756,0.00006266747,0.00002740284,0.0001062861,0.0000893815,0.00003869519],"domain_scores_gemma":[0.9990527,0.0002840325,0.0003637623,0.00007333592,0.0001479105,0.00007834074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007039209,0.0001439163,0.8549175,0.0001546397,0.0003138601,0.00006301572,0.00005920705,0.004872943,0.08821028,0.0001434182,0.0006741674,0.04974308],"study_design_scores_gemma":[0.00006419154,0.001061991,0.8490434,0.00004095193,0.0004375726,0.000801368,0.00007290341,0.05392108,0.09059655,0.0009981707,0.002916491,0.00004540494],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860591,0.001169343,0.01022099,0.0001839697,0.00001294447,0.00004369726,0.001817917,0.0001505437,0.0003416151],"genre_scores_gemma":[0.9911617,0.0001771784,0.007039825,0.00005125149,0.00001071553,0.0000223893,0.001316256,0.000009247858,0.0002113339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001318942,"threshold_uncertainty_score":0.005683005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03493231504737748,"score_gpt":0.3022917515052868,"score_spread":0.2673594364579093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}