{"id":"W2969426288","doi":"10.1016/j.cgh.2019.08.025","title":"Response to Placebo, Measured by Endoscopic Evaluation of Crohn’s Disease Activity, in a Pooled Analysis of Data From 5 Randomized Controlled Induction Trials","year":2019,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"Takeda Canada; Bristol-Myers Squibb Canada; Allergan; Atlantic Healthcare; Shire; Celgene; AbbVie Canada; Tillotts Pharma; Boehringer Ingelheim; Janssen Pharmaceuticals; Gilead Sciences; Akebia Therapeutics; AbbVie; Merck; Dr. Falk Pharma; Pfizer; Covidien; Duke Clinical Research Institute; Teva Pharmaceutical Industries","keywords":"Medicine; Crohn's disease; Placebo; Pooled analysis; Randomized controlled trial; Meta-analysis; Internal medicine; Disease; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01822242,0.003060181,0.01581473,0.001634307,0.0004743311,0.002422581,0.001128334,0.002554313,0.002185483],"category_scores_gemma":[0.01537272,0.001158017,0.01691356,0.001657929,0.001418445,0.002093747,0.001174461,0.002989654,0.0002754327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001072752,"about_ca_system_score_gemma":0.0008559088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007471478,"about_ca_topic_score_gemma":0.001423617,"domain_scores_codex":[0.9840634,0.01066911,0.002469942,0.001406837,0.0008064363,0.0005843719],"domain_scores_gemma":[0.9889638,0.00685586,0.002465569,0.0008745266,0.0004814187,0.0003589401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8126398,0.0003133772,0.004283364,0.01136873,0.1559155,0.00008552136,0.00008346962,0.0009348167,0.001504132,0.0000942941,0.0004393289,0.01233764],"study_design_scores_gemma":[0.5478315,0.03761167,0.03025468,0.001521174,0.3777208,0.0001805305,0.0001551183,0.001343294,0.001161884,0.0007283432,0.001375323,0.0001157293],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6209293,0.3616571,0.006452662,0.0008358381,0.001528748,0.002667127,0.002690972,0.0003372295,0.00290115],"genre_scores_gemma":[0.9698364,0.02310001,0.002229777,0.0007796098,0.0004305053,0.001304282,0.001666917,0.00005240253,0.0006000453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01822242,"threshold_uncertainty_score":0.09637052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07007045522233137,"score_gpt":0.3866655662402816,"score_spread":0.3165951110179503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}