{"id":"W2969495394","doi":"10.1038/s41593-019-0462-8","title":"Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex","year":2019,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":123,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Université Laval","funders":"National Institute on Aging; National Institute on Drug Abuse; Hope for Depression Research Foundation; National Institute of General Medical Sciences; National Institute of Mental Health; U.S. Department of Health and Human Services","keywords":"CREB; Prefrontal cortex; Biology; Transcription factor; Neuroscience; Transcriptional regulation; Promoter; Regulation of gene expression; Enhancer; Gene regulatory network; Gene expression; Genetics; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000128923,0.0002591632,0.0002925257,0.0002178714,0.000318724,0.0002693654,0.0003815306,0.0002312854,0.002631436],"category_scores_gemma":[0.0002119163,0.0001976389,0.0003807461,0.0001178565,0.000353387,0.000277527,0.0004433497,0.0006280377,0.0004116941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004125593,"about_ca_system_score_gemma":0.00038608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001723178,"about_ca_topic_score_gemma":0.002718573,"domain_scores_codex":[0.9998075,0.0000107993,0.000006537699,0.00007417731,0.00002759989,0.00007327362],"domain_scores_gemma":[0.9998658,0.000008546102,0.00004612883,0.00001228022,0.00001707999,0.00005017916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005561645,0.00003150619,0.002566502,0.0000443379,0.0000261253,0.0001817141,0.00004931724,0.0001803468,0.9916235,0.0004633869,0.0004232962,0.003853796],"study_design_scores_gemma":[0.0002458003,0.0004383577,0.3364718,0.00005303949,0.0001778349,0.001115466,0.0006010067,0.006685429,0.6449747,0.002226917,0.00695357,0.00005610026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898446,0.0005652221,0.006683875,0.0003101752,0.00008499498,0.00001484282,0.0009636048,0.0002094779,0.001323216],"genre_scores_gemma":[0.9963147,0.0001900755,0.0009991886,0.0000827235,0.00001434829,0.00002231366,0.0005067373,0.00004327023,0.001826707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002631436,"threshold_uncertainty_score":0.00880301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008216444015765961,"score_gpt":0.2409549024424719,"score_spread":0.232738458426706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}