{"id":"W2969586830","doi":"10.1007/s12403-019-00318-8","title":"Human-Based Exposure Levels of Perfluoroalkyl Acids May Induce Harmful Effects to Health by Disrupting Major Components of Androgen Receptor Signalling In Vitro","year":2019,"lang":"en","type":"article","venue":"Exposure and Health","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; Queen's University; Department for Education, UK Government; Queen's University Belfast; European Commission","keywords":"Transactivation; Androgen receptor; Chemistry; Testosterone (patch); In vitro; Human health; Chromosomal translocation; Pharmacology; Biology; Prostate cancer; Endocrinology; Biochemistry; Gene; Transcription factor; Medicine; Cancer; Genetics; Environmental health","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001455837,0.0002363949,0.0006522194,0.0001250738,0.0001690241,0.00002002762,0.0002955579,0.0001121248,0.0003774228],"category_scores_gemma":[0.00001684989,0.0002213215,0.00006563256,0.0003839636,0.0000983756,0.0001478623,0.0001177576,0.0003190153,0.00004167853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615966,"about_ca_system_score_gemma":0.0001213505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003196868,"about_ca_topic_score_gemma":0.0003012716,"domain_scores_codex":[0.9971336,0.0003513351,0.0007005692,0.0005013993,0.0006046302,0.0007085348],"domain_scores_gemma":[0.9988778,0.0001142906,0.0002813283,0.0002942567,0.00001895369,0.0004133924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000124443,0.0001913187,0.3264343,0.0005321612,0.00001074128,0.000001699151,0.002444117,0.00008718232,0.5990294,0.00000662233,0.0006244943,0.07051346],"study_design_scores_gemma":[0.004048714,0.003923448,0.5973096,0.0007332682,0.000006834773,0.000003489491,0.0006482222,0.0003125567,0.3881721,0.00002901468,0.004262668,0.0005499771],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893414,0.008014064,0.0000750967,0.001173373,0.00008075895,0.0009782008,0.0001407946,0.00001697,0.00017939],"genre_scores_gemma":[0.9975363,0.00009570075,0.001271166,0.0007525714,0.00002821872,0.00002715791,0.00005221784,0.00002721898,0.0002094511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2708753,"threshold_uncertainty_score":0.9025227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03718492841345905,"score_gpt":0.3255003336703998,"score_spread":0.2883154052569408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}