{"id":"W2969586830","doi":"10.1007/s12403-019-00318-8","title":"Human-Based Exposure Levels of Perfluoroalkyl Acids May Induce Harmful Effects to Health by Disrupting Major Components of Androgen Receptor Signalling In Vitro","year":2019,"lang":"en","type":"article","venue":"Exposure and Health","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; Queen's University; Department for Education, UK Government; Queen's University Belfast; European Commission","keywords":"Transactivation; Androgen receptor; Chemistry; Testosterone (patch); In vitro; Human health; Chromosomal translocation; Pharmacology; Biology; Prostate cancer; Endocrinology; Biochemistry; Gene; Transcription factor; Medicine; Cancer; Genetics; Environmental health","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002990619,0.0003325767,0.000183922,0.0001662641,0.0001921679,0.0003323067,0.00009930555,0.0003315112,0.002222405],"category_scores_gemma":[0.0002646228,0.0001089374,0.0002235834,0.0001959361,0.0002291997,0.0001113945,0.0001251048,0.0002562638,0.0002894739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000232997,"about_ca_system_score_gemma":0.0003514802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004176604,"about_ca_topic_score_gemma":0.004701492,"domain_scores_codex":[0.999665,0.0001080627,0.00002159277,0.00006123745,0.00008133685,0.00006276795],"domain_scores_gemma":[0.9998338,0.00006236639,0.00003185519,0.00001433693,0.00004028474,0.00001732844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004325829,0.00006106582,0.001763281,0.00005377683,0.00001504428,0.00006226786,0.00005057679,0.0001210206,0.9952161,0.00004668582,0.0000946841,0.00208292],"study_design_scores_gemma":[0.00001350028,0.002871274,0.01561255,0.00001561385,0.00004169861,0.0002553161,0.0001928422,0.0003090345,0.9765912,0.00007110551,0.004015658,0.00001019458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920196,0.002390027,0.002728272,0.0001143014,0.00005578252,0.00003558796,0.0005140321,0.00002645924,0.002115917],"genre_scores_gemma":[0.9926181,0.001240384,0.00175346,0.0001015684,0.00001417448,0.00003953041,0.0007966962,0.000007232521,0.003428831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004176604,"threshold_uncertainty_score":0.008304596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03718492841345905,"score_gpt":0.3255003336703998,"score_spread":0.2883154052569408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}