{"id":"W2969616911","doi":"10.1101/741512","title":"Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Eating Disorders and Behaviors","field":"Psychology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hospital for Sick Children; St. Joseph’s Healthcare Hamilton; University of Toronto; University Health Network; Centre for Addiction and Mental Health","funders":"Cilag; North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; Seqirus; Mitsubishi Tanabe Pharma Corporation; Servier; Genesis Pharma; National and Kapodistrian University of Athens; Bundesministerium für Bildung und Forschung; King's College London; Teva Pharmaceutical Industries; Department of Health and Social Care; American Society of Clinical Psychopharmacology; National Institute of Mental Health; Avanir Pharmaceuticals; Maudsley Charity; Jazz Pharmaceuticals; Wellcome Trust; Lilly Deutschland; Vrije Universiteit Amsterdam; H. Lundbeck A/S; Sunovion; National Institute for Health and Care Research; Lundbeckfonden; Eli Lilly and Company; Assurex Health; Louis and Harold Price Foundation; Deutsche Forschungsgemeinschaft; Mayo Foundation for Medical Education and Research; Indivior; Sanofi; Pfizer; Robert Bosch Stiftung; GlaxoSmithKline; AstraZeneca; Bristol-Myers Squibb","keywords":"Bulimia nervosa; Eating disorders; Binge-eating disorder; Binge eating; Substance dependence; Psychiatry; Genetic correlation; Anorexia nervosa; Twin study; Genome-wide association study; Alcohol use disorder; Cannabis; Disordered eating; Psychology; Substance abuse; Clinical psychology; Single-nucleotide polymorphism; Medicine; Genetic variation; Genetics; Heritability; Biology; Population; Alcohol; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003454669,0.0004700955,0.0005741595,0.001721178,0.0004971334,0.001010371,0.00059911,0.0007860546,0.003121395],"category_scores_gemma":[0.009561811,0.0003506069,0.001039787,0.002763995,0.0009071243,0.0003888379,0.001046433,0.0006569486,0.0001406208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001877851,"about_ca_system_score_gemma":0.0003091623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004686436,"about_ca_topic_score_gemma":0.004931579,"domain_scores_codex":[0.9967377,0.001528207,0.0003721967,0.0008593533,0.000367079,0.0001356493],"domain_scores_gemma":[0.9889868,0.006566191,0.002496953,0.000879186,0.0006723974,0.0003984831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003336573,0.0000285213,0.9889812,0.0001238746,0.003798276,0.0002998622,0.0001702274,0.0002384873,0.001585152,0.0002060879,0.0002104553,0.00402408],"study_design_scores_gemma":[0.00003249306,0.0000528871,0.9966839,0.00004563476,0.001164673,0.0004719849,0.0001147657,0.0005304222,0.0001782655,0.0003917499,0.0003221704,0.00001101464],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914255,0.004678746,0.001664684,0.00037963,0.00003359485,0.00001540624,0.0008028933,0.00002683866,0.0009726923],"genre_scores_gemma":[0.9980797,0.0008125851,0.0005887215,0.00006712122,0.00002839517,0.00001044919,0.0003176855,0.000007529872,0.0000877584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004686436,"threshold_uncertainty_score":0.01827025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03403900890676337,"score_gpt":0.270956204030648,"score_spread":0.2369171951238846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}