{"id":"W2969679683","doi":"10.1186/s12974-019-1558-5","title":"The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis","year":2019,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Ocular Diseases and Behçet’s Syndrome","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Ottawa","keywords":"Inflammasome; Pathogenesis; XIAP; Neurology; Medicine; Neuroscience; Biology; Inflammation; Immunology; Genetics; Caspase; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003242145,0.0003010997,0.0002320251,0.0003232638,0.0001783209,0.0003519125,0.0001524792,0.0003557062,0.001711788],"category_scores_gemma":[0.0002578444,0.0001010961,0.0003119846,0.0002404929,0.0003681058,0.0002757701,0.0002198544,0.0007306784,0.0003156375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002441739,"about_ca_system_score_gemma":0.0001341295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001034821,"about_ca_topic_score_gemma":0.00008092797,"domain_scores_codex":[0.999835,0.00002612335,0.00002586864,0.00003201008,0.00004284218,0.00003812019],"domain_scores_gemma":[0.9997326,0.00002931115,0.0001396727,0.00002095369,0.00003778105,0.00003973794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005080253,0.0000447396,0.001752299,0.0001419544,0.0000182505,0.0002022503,0.00002464928,0.00002640717,0.9952466,0.00008081517,0.00007028881,0.00188366],"study_design_scores_gemma":[0.00006722671,0.001038882,0.1060354,0.00005817859,0.0001202084,0.003143785,0.0001271837,0.0006334006,0.8843412,0.0003803389,0.004041643,0.00001252173],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805402,0.01430328,0.003122413,0.0003618399,0.0000613899,0.00003985724,0.0003742812,0.00007021584,0.001126494],"genre_scores_gemma":[0.9944804,0.003076653,0.0013833,0.00008994633,0.00003199727,0.00004873741,0.0002171457,0.000006588774,0.0006653471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001711788,"threshold_uncertainty_score":0.005726516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546962190332779,"score_gpt":0.2625694527514513,"score_spread":0.2470998308481235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}