{"id":"W2969680749","doi":"10.1002/jlb.5bt0119-016r","title":"At the bench: Engineering the next generation of cancer vaccines","year":2019,"lang":"en","type":"review","venue":"Journal of Leukocyte Biology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Congressionally Directed Medical Research Programs; Division of Chemical, Bioengineering, Environmental, and Transport Systems; Vanderbilt University; Stand Up To Cancer; Melanoma Research Alliance; Entertainment Industry Foundation; National Science Foundation; Canadian Institutes of Health Research; American Cancer Society; Alex's Lemonade Stand Foundation for Childhood Cancer; American Association for Cancer Research; Vanderbilt-Ingram Cancer Center","keywords":"Immunogenicity; Immune system; Tumor microenvironment; Cancer; Immunotherapy; Cancer immunotherapy; Cancer vaccine; Immunology; Biology; Antigen; Computational biology; Medicine; Cancer research","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001206358,0.0003466179,0.0004417687,0.0004036774,0.0003399758,0.002310835,0.0004946426,0.001083538,0.003733119],"category_scores_gemma":[0.001087147,0.0002727224,0.0004592026,0.0002525987,0.0008230872,0.003088407,0.0008125389,0.002494804,0.001900708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006512577,"about_ca_system_score_gemma":0.0009518901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001916813,"about_ca_topic_score_gemma":0.0003430711,"domain_scores_codex":[0.9995592,0.0001212271,0.0000244068,0.00004713817,0.0001630024,0.00008494773],"domain_scores_gemma":[0.9997212,0.00009708053,0.00003875155,0.00003469842,0.00005735196,0.00005086799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002729389,0.0002628505,0.001521551,0.002552027,0.00008884289,0.0005446804,0.000389034,0.004028752,0.3761343,0.2011649,0.0521471,0.360893],"study_design_scores_gemma":[0.00005369266,0.0007064618,0.0006828645,0.0005524502,0.00008080502,0.0007002479,0.0002951588,0.003076759,0.1157839,0.05691123,0.8211159,0.00004059603],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08700015,0.5229883,0.2321916,0.0700087,0.01179181,0.0004599856,0.0008308938,0.00154516,0.07318358],"genre_scores_gemma":[0.3214365,0.4478444,0.1580976,0.0241443,0.005772534,0.0004778754,0.0008915307,0.0005094113,0.04082586],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003733119,"threshold_uncertainty_score":0.01248854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.120036794949781,"score_gpt":0.3418591436288819,"score_spread":0.2218223486791009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}