{"id":"W2969690755","doi":"10.1007/s40262-019-00809-6","title":"Development and Validation of a Population-Pharmacokinetic Model for Rurioctacog Alfa Pegol (Adynovate®): A Report on Behalf of the WAPPS-Hemo Investigators Ad Hoc Subgroup","year":2019,"lang":"en","type":"article","venue":"Clinical Pharmacokinetics","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Impact; McMaster University; University of Waterloo","funders":"","keywords":"Covariate; Medicine; Population; Bayesian probability; Pharmacokinetics; NONMEM; Statistics; Oncology; Internal medicine; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03585883,0.001829373,0.002790421,0.0004581884,0.0003578393,0.00229378,0.002507536,0.001269454,0.002268844],"category_scores_gemma":[0.03137319,0.0009436674,0.00538888,0.0004207822,0.0003459067,0.001016805,0.001080011,0.00231805,0.001207664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001611132,"about_ca_system_score_gemma":0.006394592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005711391,"about_ca_topic_score_gemma":0.002176317,"domain_scores_codex":[0.9914153,0.006027907,0.0004252046,0.0008296712,0.001057047,0.000244853],"domain_scores_gemma":[0.9905821,0.005391778,0.0008487627,0.001441933,0.001517285,0.0002181178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.1235688,0.004123945,0.09162544,0.00355245,0.05669878,0.0004950771,0.000540314,0.360077,0.01287778,0.004444918,0.04972459,0.2922709],"study_design_scores_gemma":[0.03367394,0.01610347,0.0510488,0.0004450656,0.02863143,0.0006295347,0.000203126,0.7949419,0.02308123,0.006000601,0.04488946,0.0003514382],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5369864,0.004914096,0.3886566,0.002581631,0.001165686,0.02084994,0.03217668,0.003075685,0.009593269],"genre_scores_gemma":[0.817582,0.002207077,0.1254631,0.001835228,0.0004415007,0.01543041,0.03024853,0.001234728,0.005557346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03585883,"threshold_uncertainty_score":0.1896418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1038628492975431,"score_gpt":0.4192405470228734,"score_spread":0.3153776977253303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}