{"id":"W2969721658","doi":"10.1038/s41386-019-0485-6","title":"Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals","year":2019,"lang":"en","type":"review","venue":"Neuropsychopharmacology","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":235,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute on Aging; National Center for Mental Health; European Regional Development Fund; Instituto de Salud Carlos III; Medical Research Council; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Dalhousie University; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Norges Forskningsråd; Dainippon Sumitomo Pharma; National Institute of Mental Health; Fondation pour la Recherche Médicale; South African Medical Research Council; Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya; Generalitat de Catalunya; University of Edinburgh; Sanofi; European Commission; Nova Scotia Health Research Foundation; Deutsche Forschungsgemeinschaft; H. Lundbeck A/S; Centres de Recerca de Catalunya; Ministerio de Ciencia, Innovación y Universidades; Universitetet i Oslo; Allergan; Fundação de Amparo à Pesquisa do Estado de São Paulo; Royal College of Physicians of Edinburgh; NIH Clinical Center; Agence Nationale de la Recherche; Fondation de l'Avenir pour la Recherche Médicale Appliquée; Wellcome Trust; Biogen; Centro de Investigación Biomédica en Red de Salud Mental; National Alliance for Research on Schizophrenia and Depression","keywords":"Corpus callosum; Fractional anisotropy; White matter; Diffusion MRI; Cingulum (brain); Bipolar disorder; Medicine; Internal medicine; Psychology; Biomarker; Cardiology; Neuroscience; Magnetic resonance imaging; Lithium (medication); Biology; Radiology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006787849,0.001415749,0.003812141,0.002086596,0.0007572059,0.001718537,0.0010201,0.001108953,0.001705837],"category_scores_gemma":[0.01047718,0.000987806,0.01291487,0.003801689,0.0005457391,0.0005870733,0.00109655,0.001171838,0.0002331521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007207192,"about_ca_system_score_gemma":0.0007475545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009953889,"about_ca_topic_score_gemma":0.02118304,"domain_scores_codex":[0.9955329,0.002192416,0.0007986428,0.0009510829,0.0003513097,0.0001736707],"domain_scores_gemma":[0.9938065,0.0037477,0.001140364,0.0007236658,0.0004170651,0.0001648132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006571687,0.00004113939,0.1799032,0.01524404,0.7793705,0.0004476539,0.0002318375,0.001050588,0.001644917,0.000251171,0.001556113,0.01368721],"study_design_scores_gemma":[0.0007034129,0.0002313012,0.1764373,0.001832478,0.8169132,0.0002646346,0.0001066858,0.0005920758,0.0003539115,0.0005068723,0.002026717,0.00003144339],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3717504,0.6159937,0.00337792,0.0008637466,0.0003963287,0.0001282385,0.006150779,0.0001182507,0.001220607],"genre_scores_gemma":[0.952817,0.04188357,0.001801931,0.0004052258,0.0001228213,0.000126916,0.002548679,0.00005724471,0.0002365732],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.009953889,"threshold_uncertainty_score":0.03589803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2973544460892999,"score_gpt":0.513220610675638,"score_spread":0.2158661645863381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}