{"id":"W2969743565","doi":"10.1126/science.aax4240","title":"Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation","year":2019,"lang":"en","type":"article","venue":"Science","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":377,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Translation (biology); Phase (matter); Cell biology; Separation (statistics); Protein biosynthesis; Chemistry; Biology; Computer science; Genetics; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003270726,0.00003527262,0.0000518579,0.00004607585,0.000034118,0.00001108218,0.00004302318,0.00003006439,0.000004619721],"category_scores_gemma":[0.00002896778,0.00003254311,0.000008812726,0.00008998679,0.0001227824,0.00001904563,0.00001863437,0.00001823896,4.657738e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000436885,"about_ca_system_score_gemma":0.00004111418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000244519,"about_ca_topic_score_gemma":0.00001231257,"domain_scores_codex":[0.9995058,0.00001330199,0.0001043687,0.0001518428,0.0001510768,0.00007361754],"domain_scores_gemma":[0.9997379,0.000007354046,0.00005433989,0.00009552615,0.00007491824,0.0000299564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004526866,0.00001009817,0.006993461,0.00001607728,0.000001704369,2.55866e-8,0.000102637,0.0001406847,0.9788533,0.0001027124,5.960813e-7,0.01373341],"study_design_scores_gemma":[0.0004207803,0.0002031013,0.04969661,0.00001052347,0.000002348609,0.000001462647,0.00003511661,0.01337254,0.9360807,0.0001126277,0.00002883387,0.00003534418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974713,0.0005068114,0.001716911,0.00002685365,0.00001818854,0.0001311286,0.000002266829,0.000001479988,0.0001250844],"genre_scores_gemma":[0.9991315,0.00008912242,0.0006670359,0.000003420031,0.000007087292,0.00000118507,0.000009083357,0.000001982204,0.00008959109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04277261,"threshold_uncertainty_score":0.1327069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01395579736445874,"score_gpt":0.3145627229491408,"score_spread":0.300606925584682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}