{"id":"W2969747169","doi":"10.1371/journal.pone.0220254","title":"Proprotein convertase subtilisin/kexin type 9 (PCSK9) in Alzheimer’s disease: A genetic and proteomic multi-cohort study","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"PCSK9; Kexin; Internal medicine; Apolipoprotein B; Endocrinology; Proprotein convertase; LDL receptor; Alzheimer's disease; Apolipoprotein E; Medicine; Cholesterol; Lipoprotein; Biology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005710382,0.0002314591,0.0007008761,0.0001395763,0.00004453684,0.00002471742,0.00009331529,0.00008809668,0.0001515899],"category_scores_gemma":[0.0001246674,0.0001976011,0.0000773134,0.0002192219,0.00004931981,0.00007174732,0.00007910639,0.0002991877,0.0002196733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006239936,"about_ca_system_score_gemma":0.0002925474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001065363,"about_ca_topic_score_gemma":0.0001084923,"domain_scores_codex":[0.9977721,0.0001674148,0.0003578101,0.00060577,0.0007257125,0.000371184],"domain_scores_gemma":[0.9985729,0.00001350249,0.0000713358,0.0008727758,0.0001339184,0.0003355978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006113471,0.005846827,0.98449,0.0005460395,0.0008119001,0.0002378855,0.0002398144,0.000001169714,0.005746564,0.000004319426,0.000005285803,0.001458809],"study_design_scores_gemma":[0.005424642,0.001012705,0.9875214,0.0004009072,0.0009437172,0.00001176021,0.0001058891,0.0007726985,0.003538346,0.00001176244,0.00002419255,0.0002319748],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795216,0.004950414,0.000004420312,0.0002032576,0.0000432064,0.01513226,0.000008915646,0.00006312619,0.00007276449],"genre_scores_gemma":[0.9961491,0.0001464138,0.00229871,0.0001561582,0.0001081033,0.0007510272,0.00002153397,0.00005482852,0.0003141208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01662747,"threshold_uncertainty_score":0.8057939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04278302162070848,"score_gpt":0.2640516438290552,"score_spread":0.2212686222083467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}