{"id":"W2969767589","doi":"10.1038/s41398-019-0541-3","title":"Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults","year":2019,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; Trimbos-instituut; ZonMw; Rivierduinen; Vrije Universiteit Amsterdam; Nederlands Instituut voor Onderzoek van de Gezondheidszorg; Rijksuniversiteit Groningen; Stanley Medical Research Institute; Leids Universitair Medisch Centrum; Universiteit Leiden; GGZ Drenthe; GGZ Friesland; Universitair Medisch Centrum Groningen; GGZ inGeest; Myriad Genetics","keywords":"Overweight; Depression (economics); Body mass index; Medicine; Internal medicine; Univariate analysis; Biomarker; Cohort; Multivariate analysis; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002994838,0.0002037309,0.0003162466,0.0003787704,0.0002049778,0.0004372838,0.0001276956,0.0002483809,0.0009582484],"category_scores_gemma":[0.0008420254,0.0001674605,0.0002744557,0.0003933684,0.0001051926,0.000161211,0.0002306298,0.0002489095,0.0001171453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001301724,"about_ca_system_score_gemma":0.0001085209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002899911,"about_ca_topic_score_gemma":0.004431301,"domain_scores_codex":[0.9998704,0.00003099694,0.00001814887,0.00003346572,0.00002470886,0.00002228437],"domain_scores_gemma":[0.9995434,0.00004861151,0.0002461397,0.00002900128,0.00004453833,0.00008825877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003179873,0.00002444096,0.996821,0.00001222976,0.00007546655,0.00005720735,0.00004900176,0.0000125822,0.001054376,0.000008899382,0.00004958567,0.001517284],"study_design_scores_gemma":[0.000002193573,0.00004408103,0.9997779,0.000001490203,0.00001064369,0.00005403775,0.00002386836,0.0000249362,0.00002785166,0.000006349064,0.00002618626,5.619133e-7],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992505,0.000356041,0.00004451671,0.00001646696,0.000005590357,0.000003904582,0.0001737006,0.000001626545,0.0001475975],"genre_scores_gemma":[0.9995757,0.0001048188,0.00004544996,0.00001250241,0.000005185345,0.000002838553,0.000135876,4.338019e-7,0.0001171709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002899911,"threshold_uncertainty_score":0.005766034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00444556295842518,"score_gpt":0.2082603478262348,"score_spread":0.2038147848678096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}