{"id":"W2969809290","doi":"10.1038/s41598-019-48548-9","title":"Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Congressionally Directed Medical Research Programs; Children's Hospital of Pittsburgh; U.S. Department of Veterans Affairs; University of Alberta; Hebrew University of Jerusalem; Muscular Dystrophy Association; Children's National Hospital; Texas Children's Hospital; University of Pittsburgh; National Science Foundation; National Institutes of Health; U.S. Department of Health and Human Services; University of Minnesota; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Defense","keywords":"Duchenne muscular dystrophy; Disease; Glucocorticoid; Muscular dystrophy; Medicine; Neuromuscular disease; Bioinformatics; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003987194,0.000164947,0.0001632848,0.00007529405,0.0001673083,0.00007803518,0.000103373,0.0001024177,0.00007279136],"category_scores_gemma":[0.0001244177,0.0001530003,0.0001502885,0.0001262545,0.0002574143,0.00001015492,0.0001036484,0.00004584404,0.00002283267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009092761,"about_ca_system_score_gemma":0.0001298504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002986307,"about_ca_topic_score_gemma":0.000002672631,"domain_scores_codex":[0.998242,0.00004517268,0.0002602583,0.0009842739,0.000145267,0.0003229973],"domain_scores_gemma":[0.9986566,0.00002004213,0.000147196,0.000882483,0.000137799,0.0001558308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00051436,0.00006000857,0.01310807,0.00007737558,0.00008176757,0.00002833791,0.00002969585,0.0001139715,0.9759008,0.000120596,0.008776633,0.001188432],"study_design_scores_gemma":[0.002039561,0.0005972108,0.1398897,0.00005649589,0.00009829705,0.00009377649,0.0004244602,0.0003851465,0.1369231,0.008014414,0.7104837,0.0009941262],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941905,0.001493012,0.0002489118,0.0001541726,0.002892006,0.0007808536,0.00002052486,0.00001521278,0.0002047812],"genre_scores_gemma":[0.9971383,0.00003484801,0.0002377399,0.00009147291,0.00006626463,0.00005175341,0.0002862852,0.00002055569,0.002072777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8389777,"threshold_uncertainty_score":0.6239171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00704935776437431,"score_gpt":0.2217116272001793,"score_spread":0.214662269435805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}