{"id":"W2969848887","doi":"10.1016/j.exphem.2019.06.406","title":"ERG ENHANCER-BASED REPORTER IDENTIFIES LEUKEMIA CELLS WITH ELEVATED LEUKEMOGENIC POTENTIAL DRIVEN BY ERG-USP9X FEED-FORWARD REGULATION","year":2019,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; University of British Columbia; University Health Network; University of British Columbia Hospital; Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Erg; Enhancer; Cancer research; Leukemia; Biology; Chemistry; Genetics; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008425522,0.000273281,0.0002899431,0.00007061045,0.0001022707,0.00003747493,0.000192046,0.0002877171,0.0005799189],"category_scores_gemma":[0.000008292743,0.0002526278,0.0001248512,0.0001033573,0.0001455825,0.00002103533,0.00008557463,0.0001012154,0.0001418658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001204452,"about_ca_system_score_gemma":0.0001634158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003112535,"about_ca_topic_score_gemma":0.00001272511,"domain_scores_codex":[0.9982957,0.00008399958,0.0004160827,0.0006223632,0.0002367497,0.0003451493],"domain_scores_gemma":[0.9990385,0.000006686999,0.000269607,0.0005105549,0.00007743723,0.00009721206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003472957,0.00008536954,0.0004685635,0.0000212651,0.00006627075,0.00001066679,0.00003358067,0.0001450649,0.9872919,0.0001583087,0.01134098,0.00003074902],"study_design_scores_gemma":[0.00154866,0.0004981614,0.0001235712,0.00002617488,0.00001532805,0.00009654952,0.0001632538,0.000510903,0.9935669,0.00001348356,0.003114097,0.0003228813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950396,0.001127784,0.001791932,0.00007882786,0.0005306466,0.0005208037,0.00001383657,0.00005262135,0.0008439793],"genre_scores_gemma":[0.9931387,0.00000968618,0.0006145414,0.0002225927,0.00008967674,0.00007258255,0.0007948185,0.00004502541,0.005012388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008226881,"threshold_uncertainty_score":0.9999926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003442502074547255,"score_gpt":0.2201769183312246,"score_spread":0.2167344162566773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}