{"id":"W2969848887","doi":"10.1016/j.exphem.2019.06.406","title":"ERG ENHANCER-BASED REPORTER IDENTIFIES LEUKEMIA CELLS WITH ELEVATED LEUKEMOGENIC POTENTIAL DRIVEN BY ERG-USP9X FEED-FORWARD REGULATION","year":2019,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute; University of British Columbia; University Health Network; University of British Columbia Hospital; Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Erg; Enhancer; Cancer research; Leukemia; Biology; Chemistry; Genetics; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000327648,0.0004099848,0.0003989401,0.0005663009,0.0002629644,0.0006594336,0.0002716173,0.0005220287,0.003756467],"category_scores_gemma":[0.0001388348,0.000220881,0.0004454354,0.0002959667,0.0004477568,0.0003140991,0.0004149871,0.001177383,0.001145334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004309221,"about_ca_system_score_gemma":0.0002412878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005023023,"about_ca_topic_score_gemma":0.0008706594,"domain_scores_codex":[0.9996411,0.00005354204,0.00003903667,0.00007834368,0.00009343091,0.00009453927],"domain_scores_gemma":[0.9998355,0.0000410964,0.00003977931,0.00002286271,0.00001612771,0.00004466281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001423763,0.0000467842,0.0001849328,0.00001190174,0.000002689488,0.00003520273,0.00001573851,0.00004217794,0.9984,0.0003164634,0.00005876975,0.0007428576],"study_design_scores_gemma":[0.00002123226,0.0000823634,0.001503901,0.00000263637,0.000008389929,0.0001379913,0.00002787161,0.0009101703,0.9956702,0.00005060494,0.001580977,0.000003635648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687812,0.0005382926,0.02328718,0.0003579781,0.0000792053,0.000123663,0.002930183,0.0006279357,0.003274304],"genre_scores_gemma":[0.9774417,0.0003517947,0.01091055,0.0001065396,0.00001462457,0.00008202485,0.002888593,0.0001471209,0.008056971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003756467,"threshold_uncertainty_score":0.01256663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003442502074547255,"score_gpt":0.2201769183312246,"score_spread":0.2167344162566773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}