{"id":"W2969874497","doi":"10.1007/s00401-019-02065-1","title":"Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant","year":2019,"lang":"en","type":"letter","venue":"Acta Neuropathologica","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Prince Edward Island","funders":"Cure Alzheimer's Fund","keywords":"splice; Disease; Subcellular localization; Action (physics); Alzheimer's disease; CD33; Neuroscience; Medicine; Biology; Genetics; Pathology; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135657,0.0003170353,0.0005137916,0.00008396653,0.0001693672,0.00001795487,0.0002785488,0.0002716588,0.00004542672],"category_scores_gemma":[0.0005585951,0.0001621732,0.0002518812,0.0001977757,0.0004278786,0.00007202986,0.0002112849,0.0007737846,0.00001066574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000349076,"about_ca_system_score_gemma":0.0001796579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005117652,"about_ca_topic_score_gemma":8.685742e-7,"domain_scores_codex":[0.9975408,0.0006884292,0.0003080157,0.0004867297,0.0006639665,0.0003119993],"domain_scores_gemma":[0.9976989,0.0006582018,0.0004672568,0.0008658304,0.0002282394,0.00008156172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.02232139,0.005495728,0.03169938,0.008652747,0.05780363,0.03277159,0.002164621,0.0002175376,0.114707,0.005649663,0.7108456,0.007671065],"study_design_scores_gemma":[0.02188939,0.01464743,0.6065648,0.004338478,0.08207072,0.002906024,0.001191385,0.005729431,0.0881028,0.02590049,0.1432523,0.003406777],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1173758,0.03675613,0.006332571,0.8092369,0.002190912,0.02291173,0.002632767,0.0003159109,0.002247231],"genre_scores_gemma":[0.9464709,0.0006124959,0.00001850444,0.05241793,0.0001972169,0.00007176547,0.0001046251,0.00004581733,0.00006079208],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8290951,"threshold_uncertainty_score":0.6613232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0372176975111414,"score_gpt":0.2731581333113473,"score_spread":0.2359404358002058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}