{"id":"W2969894586","doi":"10.1158/1541-7786.mcr-19-0461","title":"A Hypoxia-Inducible HIF1–GAL3ST1-Sulfatide Axis Enhances ccRCC Immune Evasion via Increased Tumor Cell–Platelet Binding","year":2019,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Cancer research; Hypoxia (environmental); Evasion (ethics); Immune system; Hypoxia-inducible factors; Platelet; Chemistry; Immune escape; Cell; Biology; Tumor cells; Immunology; Gene; Biochemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001454744,0.0004249522,0.0005206068,0.0003818121,0.0003000217,0.0001415078,0.0008161678,0.0002903118,0.000747235],"category_scores_gemma":[0.0001721837,0.0004189437,0.0003132269,0.0007979804,0.000200283,0.00002454907,0.000529525,0.0006685624,0.0003976865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001764234,"about_ca_system_score_gemma":0.0008026407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003207858,"about_ca_topic_score_gemma":0.0001644412,"domain_scores_codex":[0.9953595,0.000501119,0.0004983844,0.001235581,0.001129298,0.001276129],"domain_scores_gemma":[0.9976796,0.00005400035,0.0001730413,0.001298725,0.0004490604,0.0003456093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003815835,0.0001242247,0.0002721025,0.0001529591,0.0001098906,0.00002746463,0.00008973573,0.00007365492,0.990882,0.00002167877,0.002653045,0.005211704],"study_design_scores_gemma":[0.001706248,0.0003523994,0.0005203134,0.00009599885,0.00002551936,0.00002741748,0.0001086578,0.00008292258,0.8676109,0.00007716368,0.12894,0.0004524598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9709005,0.02063567,0.0004336486,0.0001744926,0.001274926,0.001105646,0.00006492051,0.00003963511,0.005370569],"genre_scores_gemma":[0.9919765,0.001842685,0.0003718503,0.0002801309,0.0009400141,0.0003775433,0.0001589894,0.0001257988,0.003926474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.126287,"threshold_uncertainty_score":0.9998263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02086201094316072,"score_gpt":0.3145234294844081,"score_spread":0.2936614185412474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}