{"id":"W2969895325","doi":"10.1038/s41467-019-11791-9","title":"Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Government of Canada; Compute Canada","keywords":"Chromatin; Enhancer; Heterochromatin; Scaffold/matrix attachment region; Transcription factor; Biology; ChIA-PET; Pioneer factor; Chromatin remodeling; Cell biology; Histone; Genetics; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002665597,0.0003091216,0.000280688,0.0002111428,0.0002069865,0.000557146,0.0002727859,0.000290367,0.00275327],"category_scores_gemma":[0.0003293664,0.000244828,0.0002983954,0.00009755368,0.0003435179,0.0003708632,0.0008351654,0.0006066695,0.0007898603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003728278,"about_ca_system_score_gemma":0.0002700707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006170245,"about_ca_topic_score_gemma":0.00181501,"domain_scores_codex":[0.9996402,0.00003213839,0.00001641855,0.0001273729,0.0001043764,0.0000794304],"domain_scores_gemma":[0.9995376,0.0001405127,0.00007223151,0.0001074505,0.00003112006,0.0001111318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002473246,0.000004467006,0.0003203126,0.000008894986,0.00000177136,0.00002854697,0.000009015635,0.00001877569,0.9987459,0.0001638331,0.00001196937,0.0006616978],"study_design_scores_gemma":[0.000007789257,0.0000602722,0.01079702,0.000002785521,0.000006315729,0.0002147917,0.00002957415,0.001568197,0.985324,0.0001530597,0.001830742,0.00000541156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984998,0.000889518,0.01050767,0.0000499385,0.00002153119,0.00001735851,0.0001361348,0.0001765249,0.003203238],"genre_scores_gemma":[0.9924774,0.0001816643,0.003437787,0.00003048804,0.000007362389,0.00001163763,0.0002125833,0.0000553063,0.003585843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00275327,"threshold_uncertainty_score":0.009210587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008407535701371798,"score_gpt":0.2514748135028843,"score_spread":0.2430672778015125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}