{"id":"W2969951593","doi":"10.1093/neuonc/noz137","title":"Patient-derived xenografts of central nervous system metastasis reveal expansion of aggressive minor clones","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Flinn Foundation","keywords":"Biology; Somatic cell; Cancer research; Metastasis; Nonsynonymous substitution; Phenotype; Pathology; Cancer; Gene; Genome; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006124268,0.0001545252,0.0003792099,0.00006895697,0.00002998328,0.000004185653,0.0001570722,0.0001503845,0.00003208781],"category_scores_gemma":[0.00008288543,0.0001327161,0.0001573936,0.00009590472,0.0001053578,0.000005661354,0.0001606607,0.00008606948,0.00001062463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005565408,"about_ca_system_score_gemma":0.0002444407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002923864,"about_ca_topic_score_gemma":0.00007916708,"domain_scores_codex":[0.9985478,0.0002341264,0.0003297045,0.0003414401,0.0001935856,0.0003533321],"domain_scores_gemma":[0.9988073,0.00004565717,0.0005022661,0.0003707934,0.0001489243,0.0001250231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009635098,0.0001698846,0.004624914,0.0001350429,0.0001449814,0.00007694796,0.0001292935,0.00002650744,0.9685562,0.00001276422,0.0009598836,0.02420013],"study_design_scores_gemma":[0.001671933,0.004652524,0.003293948,0.00003909712,0.00005505766,0.00008496037,0.0002867915,0.000009557308,0.980933,0.000003571307,0.008866381,0.000103244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972954,0.001053176,0.00001468741,0.00006742072,0.0004318676,0.0004903699,0.0001411314,0.000008213019,0.0004976754],"genre_scores_gemma":[0.9991968,0.0002244297,0.0002472526,0.00007518917,0.0000758456,0.00003739541,0.0001025438,0.00002001813,0.0000204785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02409688,"threshold_uncertainty_score":0.5412004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01203479519655484,"score_gpt":0.2756917279217693,"score_spread":0.2636569327252145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}