{"id":"W2969951593","doi":"10.1093/neuonc/noz137","title":"Patient-derived xenografts of central nervous system metastasis reveal expansion of aggressive minor clones","year":2019,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Flinn Foundation","keywords":"Biology; Somatic cell; Cancer research; Metastasis; Nonsynonymous substitution; Phenotype; Pathology; Cancer; Gene; Genome; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001964078,0.0002256036,0.0001762393,0.0002064935,0.0001060371,0.000236784,0.0001253373,0.0001898162,0.001344052],"category_scores_gemma":[0.0001945293,0.00008780834,0.0001481564,0.0001032361,0.0001177096,0.0001071996,0.0002136963,0.0005453107,0.0002575618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001791337,"about_ca_system_score_gemma":0.000137447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003594408,"about_ca_topic_score_gemma":0.0006617725,"domain_scores_codex":[0.9999063,0.00001444185,0.00001210364,0.00002378612,0.00002675238,0.00001659657],"domain_scores_gemma":[0.99978,0.00006959428,0.00003915851,0.00003596054,0.0000220575,0.00005316144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001882236,0.00008691248,0.004397283,0.00002288668,0.00001222643,0.0002639336,0.0000380363,0.0001500705,0.9915066,0.0002125875,0.0001018284,0.003019508],"study_design_scores_gemma":[0.00006737048,0.002898503,0.04757845,0.00001285634,0.00005964319,0.007529768,0.0000859501,0.00357104,0.9328951,0.0002279775,0.005063406,0.000009987843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958191,0.0002273397,0.002733165,0.00002400555,0.000006208407,0.00005060507,0.0003009933,0.00004652724,0.0007920541],"genre_scores_gemma":[0.9956956,0.0001691439,0.002449285,0.00002291694,0.000002789401,0.0000349372,0.0007173271,0.00001351102,0.0008945419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001344052,"threshold_uncertainty_score":0.004496336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01203479519655484,"score_gpt":0.2756917279217693,"score_spread":0.2636569327252145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}