{"id":"W2969953468","doi":"10.1002/ejhf.1575","title":"Safety, Tolerability and Efficacy of Rapid Optimization, Helped by NT-proBNP and GDF-15, of Heart Failure Therapies (STRONG-HF): Rationale and Design for a Multicentre, Randomized, Parallel-Group Study","year":2019,"lang":"en","type":"article","venue":"European Journal of Heart Failure","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"","keywords":"Medicine; Heart failure; Tolerability; Adverse effect; Internal medicine; Clinical endpoint; Randomized controlled trial; Natriuretic peptide; Renal function; Cardiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00263641,0.0002323442,0.00102698,0.0001314959,0.00009709,0.00003213842,0.0000766084,0.00007215291,0.00009847411],"category_scores_gemma":[0.0003220653,0.0001591616,0.0001782234,0.0001165658,0.0002695365,0.0001600522,0.000043038,0.0002542711,0.000001275824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001453658,"about_ca_system_score_gemma":0.00006455672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004664019,"about_ca_topic_score_gemma":0.00000216211,"domain_scores_codex":[0.997062,0.001145711,0.001019066,0.0002698554,0.0003069052,0.0001964812],"domain_scores_gemma":[0.9979941,0.0007704929,0.0004851326,0.0001990627,0.0003705106,0.0001807612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5607082,0.007246868,0.1909832,0.002352987,0.008546514,0.00005783191,0.01999086,0.01658642,0.08226322,0.0001119282,0.1067694,0.00438262],"study_design_scores_gemma":[0.8583506,0.01594598,0.06345697,0.001607305,0.002137143,0.0008025923,0.01115137,0.009043233,0.001459574,0.0000451853,0.0351964,0.0008036373],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636238,0.007873176,0.01011479,0.01316461,0.0001153417,0.005037152,0.00002757521,0.0000167479,0.00002677885],"genre_scores_gemma":[0.9119192,0.0002774818,0.08748746,0.00009997168,0.00005926147,0.000004854367,0.00001792977,0.00003456408,0.00009925728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2976424,"threshold_uncertainty_score":0.6490421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137477136622532,"score_gpt":0.2364444015651085,"score_spread":0.2250696301988831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}