{"id":"W2969953468","doi":"10.1002/ejhf.1575","title":"Safety, Tolerability and Efficacy of Rapid Optimization, Helped by NT-proBNP and GDF-15, of Heart Failure Therapies (STRONG-HF): Rationale and Design for a Multicentre, Randomized, Parallel-Group Study","year":2019,"lang":"en","type":"article","venue":"European Journal of Heart Failure","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"","keywords":"Medicine; Heart failure; Tolerability; Adverse effect; Internal medicine; Clinical endpoint; Randomized controlled trial; Natriuretic peptide; Renal function; Cardiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03290945,0.00327679,0.005287084,0.0009779382,0.0009688442,0.001597369,0.002466667,0.00401513,0.005215225],"category_scores_gemma":[0.0224847,0.001702598,0.004010806,0.0008611259,0.004182612,0.002896762,0.001697656,0.003340501,0.001180086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001389467,"about_ca_system_score_gemma":0.002352296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003786494,"about_ca_topic_score_gemma":0.0005762661,"domain_scores_codex":[0.9747678,0.01947269,0.001664487,0.001739653,0.00135241,0.001003065],"domain_scores_gemma":[0.9842741,0.004998529,0.003590057,0.003137895,0.001341869,0.002657488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9738222,0.01810655,0.001089977,0.0002264213,0.0006123466,0.00001527511,0.00004292361,0.0002374953,0.001233701,0.0000840147,0.0001294344,0.004399576],"study_design_scores_gemma":[0.8490766,0.1479679,0.001505488,0.00001700307,0.0004353939,0.00001471601,0.00001231852,0.0003189148,0.0003403186,0.0001281909,0.0001672973,0.00001588828],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9514624,0.001491107,0.003894614,0.0007436426,0.0008522929,0.03968663,0.000749291,0.0001025421,0.001017537],"genre_scores_gemma":[0.9331474,0.000662017,0.01415918,0.001527337,0.001574201,0.04712059,0.0008312048,0.0000349373,0.0009431975],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.03290945,"threshold_uncertainty_score":0.1740439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137477136622532,"score_gpt":0.2364444015651085,"score_spread":0.2250696301988831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}