{"id":"W2970012232","doi":"10.1161/atvbaha.119.311392","title":"2018 George Lyman Duff Memorial Lecture","year":2019,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Heart Research Centre","funders":"Canadian Institutes of Health Research","keywords":"Genome-wide association study; Missing heritability problem; Expression quantitative trait loci; Genetic architecture; Genetic association; Imputation (statistics); Quantitative trait locus; Biology; Genome; Genetics; Mendelian randomization; Genomics; Computational biology; Gene; Missing data; Computer science; Genetic variants; Single-nucleotide polymorphism; Machine learning","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001484915,0.0008429957,0.0006062692,0.0009791324,0.0008448774,0.002524262,0.000882149,0.003377453,0.1064714],"category_scores_gemma":[0.006684893,0.000217803,0.0004550074,0.000252301,0.0009475134,0.0013875,0.001726083,0.004672038,0.07442424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001762145,"about_ca_system_score_gemma":0.002352327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001631507,"about_ca_topic_score_gemma":0.002825004,"domain_scores_codex":[0.9991485,0.0001193273,0.0000332538,0.0002378377,0.0003412405,0.0001198251],"domain_scores_gemma":[0.997263,0.0004227735,0.00009027985,0.0001005485,0.0008373064,0.001286226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004131283,0.00001546196,0.000248363,0.00005114196,0.000006386722,0.0002787243,0.00002378681,0.00005554119,0.0001449725,0.003087606,0.9441032,0.05194352],"study_design_scores_gemma":[0.000008779262,0.00001738069,0.0003188903,0.0001047204,0.000003207083,0.0007309744,0.00003638876,0.00006448175,0.0001066304,0.001373126,0.9972284,0.000006988259],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.002180658,0.04198749,0.002352048,0.4173563,0.3542982,0.00007059002,0.0005497504,0.000551315,0.1806536],"genre_scores_gemma":[0.02216459,0.04062079,0.002250959,0.06612494,0.1056618,0.00009707107,0.0003985262,0.0003531017,0.7623282],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.1064714,"threshold_uncertainty_score":0.3561825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620206736226986,"score_gpt":0.2595667415899715,"score_spread":0.2433646742277016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}