{"id":"W2970032913","doi":"10.1128/jvi.00810-19","title":"A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canada Excellence Research Chairs, Government of Canada; Alberta Innovates; Alberta Innovates - Health Solutions","keywords":"Virology; Hepatitis C virus; Biology; Hypervariable region; Neutralization; Antibody; Hepatocellular carcinoma; Genotype; Neutralizing antibody; Hepacivirus; Glycoprotein; Liver disease; Virus; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000194432,0.0002731841,0.0001735617,0.0001611267,0.0000881298,0.0001807511,0.000113988,0.0002549619,0.0006529307],"category_scores_gemma":[0.0002053808,0.00006380918,0.000176262,0.00007231803,0.0001281583,0.0001365645,0.0001186321,0.0003444752,0.0001222065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001422098,"about_ca_system_score_gemma":0.00009149391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003258379,"about_ca_topic_score_gemma":0.0004397337,"domain_scores_codex":[0.9998409,0.00003414534,0.00001148953,0.00002710752,0.00004410458,0.0000423339],"domain_scores_gemma":[0.9999348,0.00001743828,0.0000167939,0.000007469203,0.000009830889,0.00001370219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008345895,0.00007396684,0.0005910035,0.0000106879,0.000004455848,0.00001464177,0.00000851537,0.0001001662,0.9982141,0.00003215509,0.00001329626,0.0008536621],"study_design_scores_gemma":[0.00006313503,0.003595007,0.02019319,0.000009645141,0.00003290455,0.0006886711,0.00005441983,0.003125979,0.9707271,0.00009562843,0.001404687,0.000009642327],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990251,0.0001189655,0.0005734107,0.00001779565,0.000007571362,0.00000821009,0.00002629833,0.000006643967,0.0002158618],"genre_scores_gemma":[0.9985952,0.00008216647,0.0007885826,0.00003461771,0.000005175395,0.000004393105,0.0001084457,0.000003289832,0.0003782302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006529307,"threshold_uncertainty_score":0.002184272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944007349272795,"score_gpt":0.2897525055042742,"score_spread":0.2603124320115463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}