{"id":"W2970061330","doi":"10.3390/md17090510","title":"Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA","year":2019,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Russian Foundation for Basic Research","keywords":"Sodium channel; Biophysics; Chemistry; Skeletal muscle; Sodium; Voltage clamp; IC50; Patch clamp; Membrane potential; Conotoxin; Biochemistry; Biology; Anatomy; In vitro; Peptide; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002014716,0.000397112,0.0003672269,0.000149613,0.0000973446,0.0002336833,0.0002412199,0.0002871718,0.0005833352],"category_scores_gemma":[0.0002645754,0.0001234488,0.0001931515,0.0001637324,0.0001814676,0.0001516804,0.0002568487,0.0007334512,0.0001884739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314599,"about_ca_system_score_gemma":0.0002038407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004768112,"about_ca_topic_score_gemma":0.0005388499,"domain_scores_codex":[0.9998004,0.00003305599,0.00002273966,0.00002872847,0.00005312568,0.00006189167],"domain_scores_gemma":[0.9998883,0.00004577349,0.00001630337,0.00001172639,0.000011706,0.00002621654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001073412,0.00005451753,0.000106427,0.00003953214,0.000007855689,0.0000331779,0.00001361656,0.0001820863,0.9978755,0.00007942352,0.00003357209,0.001467059],"study_design_scores_gemma":[0.00003314273,0.001315637,0.003341602,0.000008564489,0.00001861134,0.0001290226,0.00001593532,0.002470668,0.9915215,0.00005668439,0.001084078,0.000004559945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908495,0.002801426,0.003665737,0.0001044073,0.00003741793,0.00003663427,0.0001633725,0.00007710953,0.002264351],"genre_scores_gemma":[0.995934,0.001228618,0.001422345,0.00007486023,0.0000174294,0.00004913449,0.0002394367,0.000008025913,0.00102619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005833352,"threshold_uncertainty_score":0.001951396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005511744243349717,"score_gpt":0.2010623787857788,"score_spread":0.1955506345424291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}