{"id":"W2970061330","doi":"10.3390/md17090510","title":"Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA","year":2019,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Russian Foundation for Basic Research","keywords":"Sodium channel; Biophysics; Chemistry; Skeletal muscle; Sodium; Voltage clamp; IC50; Patch clamp; Membrane potential; Conotoxin; Biochemistry; Biology; Anatomy; In vitro; Peptide; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189145,0.0001414468,0.0001566973,0.00004407325,0.00002933632,0.00001637776,0.0001089409,0.0001408824,0.0006380506],"category_scores_gemma":[0.00001809195,0.0001367755,0.00008793592,0.00007150618,0.00003022146,0.000004645065,0.0001448309,0.00005500781,0.00006660268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001280987,"about_ca_system_score_gemma":0.00002943092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000614591,"about_ca_topic_score_gemma":0.000003209216,"domain_scores_codex":[0.9991623,0.00002830933,0.0002303534,0.0002736445,0.0001232879,0.0001821002],"domain_scores_gemma":[0.9994789,0.000005157314,0.0001124114,0.0002529595,0.00009073573,0.000059827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003483782,0.0000896674,0.001166835,0.00002544703,0.00004227985,3.997311e-7,0.00005909295,0.000124574,0.9769694,0.00002917913,0.01618954,0.004955161],"study_design_scores_gemma":[0.001627725,0.0002665965,0.001247341,0.000007907527,0.00001285893,0.00000459736,0.00006823712,0.001453806,0.7542096,0.00003182414,0.2408463,0.0002232133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942701,0.00003474099,0.0002672929,0.0001427359,0.001424469,0.000246711,0.00002898097,0.0000188864,0.003566076],"genre_scores_gemma":[0.9788409,0.00001876285,0.00004047815,0.0001392686,0.0004276168,0.000007864855,0.001058769,0.0000210872,0.01944523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2246568,"threshold_uncertainty_score":0.6986206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005511744243349717,"score_gpt":0.2010623787857788,"score_spread":0.1955506345424291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}