{"id":"W2970087283","doi":"10.1152/ajpcell.00209.2019","title":"Molecular regulation of human skeletal muscle protein synthesis in response to exercise and nutrients: a compass for overcoming age-related anabolic resistance","year":2019,"lang":"en","type":"review","venue":"American Journal of Physiology-Cell Physiology","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Anabolism; mTORC1; Skeletal muscle; Sarcopenia; Biology; Anabolic Agents; Adaptive response; Bioinformatics; Endocrinology; Cell biology; PI3K/AKT/mTOR pathway; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004375999,0.0007288422,0.001198361,0.001789987,0.0002377062,0.0008871724,0.0008253511,0.001103722,0.002416092],"category_scores_gemma":[0.0004867414,0.0002338166,0.0003938738,0.001614516,0.0005065973,0.001291955,0.0006615386,0.00192883,0.002269672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006339003,"about_ca_system_score_gemma":0.0009655668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007634581,"about_ca_topic_score_gemma":0.001041152,"domain_scores_codex":[0.9998571,0.00002069549,0.00002305644,0.00003240947,0.00005218075,0.00001461176],"domain_scores_gemma":[0.9998127,0.00007177834,0.00002596983,0.000007058964,0.00006127529,0.00002127177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009501746,0.00006911843,0.0001808681,0.01914261,0.0001028017,0.0001766508,0.00005849079,0.0003375999,0.005047817,0.005786473,0.02596491,0.9430377],"study_design_scores_gemma":[0.00001892747,0.0001065946,0.001304997,0.002949972,0.00009874503,0.0009854706,0.00005427873,0.00009638377,0.001126989,0.002791294,0.990445,0.00002119954],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009209699,0.9987202,0.0001276385,0.0002519417,0.000179162,0.000002374496,0.00001328006,0.000006800485,0.0006065379],"genre_scores_gemma":[0.0004823434,0.99863,0.0001789309,0.0001376702,0.0001111753,0.00000532453,0.00002468465,0.000001276912,0.0004285265],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002416092,"threshold_uncertainty_score":0.008082688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01142454928681065,"score_gpt":0.2771684778612544,"score_spread":0.2657439285744438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}