{"id":"W2970162264","doi":"10.1186/s13223-019-0362-1","title":"Subcutaneous C1 inhibitor for prevention of attacks of hereditary angioedema: additional outcomes and subgroup analysis of a placebo-controlled randomized study","year":2019,"lang":"en","type":"article","venue":"Allergy Asthma and Clinical Immunology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; Grifols; Swedish Orphan Biovitrum; CSL Behring; BioCryst; U.S. Department of Defense; Alnylam Pharmaceuticals; Viropharma; Arrowhead Pharmaceuticals; Sanofi; GlaxoSmithKline","keywords":"Hereditary angioedema; Subgroup analysis; Medicine; Placebo; C1-inhibitor; Randomized controlled trial; Angioedema; Internal medicine; Meta-analysis; Dermatology; Alternative medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00915499,0.002654618,0.00853948,0.001101061,0.0004861029,0.001601712,0.001024724,0.002643133,0.004974706],"category_scores_gemma":[0.008365646,0.0007132204,0.01101954,0.001032736,0.0009343718,0.001004057,0.0007012823,0.002185496,0.0004346703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009643652,"about_ca_system_score_gemma":0.001353331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009741631,"about_ca_topic_score_gemma":0.001792897,"domain_scores_codex":[0.9917334,0.005647854,0.0008403076,0.0008032768,0.0004933742,0.0004817544],"domain_scores_gemma":[0.9938677,0.003118954,0.001293374,0.0007122628,0.0004792667,0.0005284432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9732309,0.00108393,0.001264385,0.001518299,0.01705824,0.00005465721,0.00003329423,0.0002014649,0.0009149351,0.00004406266,0.0001590075,0.004436817],"study_design_scores_gemma":[0.9261002,0.03717488,0.006333482,0.0001255226,0.02844356,0.00004256963,0.00004810618,0.0006686406,0.0003812085,0.0002248363,0.0004196022,0.00003736216],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571978,0.02741498,0.002344815,0.0006152725,0.001269771,0.007465263,0.001794803,0.0001625911,0.001734758],"genre_scores_gemma":[0.987556,0.003553022,0.001333724,0.000600457,0.0006959129,0.004492428,0.0008734291,0.00001907286,0.0008760452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00915499,"threshold_uncertainty_score":0.04841679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01503710812729457,"score_gpt":0.3188622584834561,"score_spread":0.3038251503561615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}