{"id":"W2970203514","doi":"10.1016/j.cbpa.2019.07.006","title":"Probing microscopic conformational dynamics in folding reactions by measuring transition paths","year":2019,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Force Microscopy Techniques and Applications","field":"Physics and Astronomy","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; John Simon Guggenheim Memorial Foundation; Simons Foundation","keywords":"Folding (DSP implementation); Energy landscape; Chemical physics; Traverse; Diffusion; Transition state; Protein folding; Molecular dynamics; Molecule; Chemistry; Downhill folding; Statistical physics; Physics; Computational chemistry; Thermodynamics; Phi value analysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009648831,0.001655636,0.001955117,0.001836466,0.0002393692,0.001170524,0.001976161,0.00168057,0.001816205],"category_scores_gemma":[0.0008209078,0.0005819596,0.0005908112,0.002347969,0.001423066,0.002643559,0.0009963547,0.002147259,0.00213964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007499337,"about_ca_system_score_gemma":0.0007297859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089282,"about_ca_topic_score_gemma":0.001433757,"domain_scores_codex":[0.9997246,0.00003521915,0.00001768274,0.0001066918,0.0000826473,0.00003332467],"domain_scores_gemma":[0.999507,0.0002645956,0.00008265318,0.00002455229,0.00008874558,0.00003244614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008894884,0.00009333572,0.0002768198,0.01148346,0.0001114968,0.00008734329,0.00004248207,0.001192581,0.02424083,0.01027269,0.01067838,0.9414316],"study_design_scores_gemma":[0.00004622433,0.0002138101,0.002217515,0.003520224,0.0002484462,0.001149368,0.00008381304,0.00195883,0.01878547,0.01800763,0.9536309,0.0001379731],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003510817,0.9959763,0.001871269,0.0003117551,0.0002589542,0.00000679598,0.00003801818,0.00002117298,0.001164699],"genre_scores_gemma":[0.002309611,0.9951435,0.001083364,0.0002419445,0.0002962413,0.00001613786,0.00006860431,0.000004643188,0.0008358903],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001976161,"threshold_uncertainty_score":0.006075859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07025963778659956,"score_gpt":0.3854386094607459,"score_spread":0.3151789716741464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}