{"id":"W2970233240","doi":"10.1093/brain/awz212","title":"Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis","year":2019,"lang":"en","type":"article","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada)","funders":"EMD Serono; Genentech; MedDay Pharmaceuticals; Ono Pharmaceutical; Schweizerische Multiple Sklerose Gesellschaft; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Research Foundation; IXICO; Multiple Sclerosis Society; UCLH Biomedical Research Centre; Bayer HealthCare; Universitätsspital Basel; Acorda Therapeutics; Novartis Foundation; University College London Hospitals NHS Foundation Trust; European Commission; Sanofi; Celgene; PTC Therapeutics; Sanofi Genzyme; National Institute on Handicapped Research; University of Texas Health Science Center at Houston; Pfizer; Biogen; National Institute for Health and Care Research; Teva Pharmaceutical Industries; F. Hoffmann-La Roche; Roche","keywords":"Multiple sclerosis; White matter; Medicine; Primary progressive aphasia; Lesion; Pathology; Magnetic resonance imaging; Disease; Psychiatry; Dementia; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007459856,0.0003805043,0.0005120363,0.0003689287,0.000222567,0.0003309563,0.0001651512,0.0004428324,0.001435376],"category_scores_gemma":[0.001587756,0.0001688256,0.0002806058,0.0002705344,0.0002126064,0.0002805735,0.0002645494,0.0004588683,0.0002654653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001780786,"about_ca_system_score_gemma":0.0002313381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001115909,"about_ca_topic_score_gemma":0.002255884,"domain_scores_codex":[0.9997581,0.00007513664,0.00003065101,0.00005599673,0.0000527155,0.00002743907],"domain_scores_gemma":[0.9987571,0.0002538728,0.0005601947,0.0000586038,0.0001089826,0.000261329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01095191,0.000632808,0.9580955,0.0001784459,0.0003033152,0.0002200426,0.00008770596,0.0004246791,0.008660281,0.0000288193,0.0003677967,0.02004876],"study_design_scores_gemma":[0.0001346298,0.001611599,0.9970899,0.00001537037,0.00005697029,0.0002654041,0.00001636199,0.0003778247,0.0002270737,0.0000331613,0.0001680213,0.000003608697],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971651,0.001620703,0.00008806355,0.00006079808,0.000009123308,0.00004169745,0.0001550301,0.00001223827,0.0008472144],"genre_scores_gemma":[0.9991544,0.0002776488,0.00009128368,0.00003967582,0.00001957474,0.00001773404,0.0001765442,0.00000164692,0.0002214325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001435376,"threshold_uncertainty_score":0.00480181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08923274566251156,"score_gpt":0.3763988604034728,"score_spread":0.2871661147409612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}