{"id":"W2970233240","doi":"10.1093/brain/awz212","title":"Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis","year":2019,"lang":"en","type":"article","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":215,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada)","funders":"EMD Serono; Genentech; MedDay Pharmaceuticals; Ono Pharmaceutical; Schweizerische Multiple Sklerose Gesellschaft; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Research Foundation; IXICO; Multiple Sclerosis Society; UCLH Biomedical Research Centre; Bayer HealthCare; Universitätsspital Basel; Acorda Therapeutics; Novartis Foundation; University College London Hospitals NHS Foundation Trust; European Commission; Sanofi; Celgene; PTC Therapeutics; Sanofi Genzyme; National Institute on Handicapped Research; University of Texas Health Science Center at Houston; Pfizer; Biogen; National Institute for Health and Care Research; Teva Pharmaceutical Industries; F. Hoffmann-La Roche; Roche","keywords":"Multiple sclerosis; White matter; Medicine; Primary progressive aphasia; Lesion; Pathology; Magnetic resonance imaging; Disease; Psychiatry; Dementia; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001211552,0.0002879191,0.0007019018,0.0002203407,0.00008996916,0.00003904136,0.000205544,0.0002628789,0.0005437661],"category_scores_gemma":[0.0008328489,0.0002209351,0.0001959211,0.0003647608,0.0002552377,0.0002602969,0.0004775867,0.0007702109,0.000690588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004670402,"about_ca_system_score_gemma":0.0004053162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002449604,"about_ca_topic_score_gemma":0.0000533686,"domain_scores_codex":[0.9966959,0.0004252119,0.0005442298,0.0007828258,0.0008315425,0.0007202951],"domain_scores_gemma":[0.9981107,0.0006430352,0.0002002364,0.0006712487,0.0001113906,0.0002633842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000786586,0.0005810715,0.8428957,0.0004753775,0.00004738864,0.00002731045,0.0001461624,0.000004741576,0.03221228,8.517309e-7,0.01082559,0.1119969],"study_design_scores_gemma":[0.00730548,0.0008914449,0.9836715,0.002171776,0.00001501846,0.000007213958,0.00003357214,0.001429866,0.001955952,0.000002635424,0.002305477,0.0002100862],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850165,0.0006608592,0.00002263092,0.008134838,0.0002260313,0.00317318,0.00001976915,0.0001133561,0.002632859],"genre_scores_gemma":[0.9956177,0.0001963293,0.0009611495,0.0006490219,0.0004508785,0.0002495928,0.00004818935,0.0000554762,0.001771612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1407757,"threshold_uncertainty_score":0.9009473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08923274566251156,"score_gpt":0.3763988604034728,"score_spread":0.2871661147409612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}