{"id":"W2970267181","doi":"10.1093/cvr/cvz217","title":"Human iPSC modelling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytes","year":2019,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Instituto de Salud Carlos III; Novo Nordisk Fonden; Agència de Gestió d'Ajuts Universitaris i de Recerca; Ministerio de Economía y Competitividad; Generalitat de Catalunya; Fondazione Cariplo; Centres de Recerca de Catalunya","keywords":"Induced pluripotent stem cell; Atrial fibrillation; Medicine; Population; Pathophysiology; Mutation; Disease; Cardiac electrophysiology; Internal medicine; Cardiac arrhythmia; Neuroscience; Bioinformatics; Genetics; Biology; Electrophysiology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000250984,0.0002416921,0.0002260023,0.0002465777,0.0001413967,0.0002819418,0.0001969257,0.0005355247,0.002175061],"category_scores_gemma":[0.0002786883,0.0000803927,0.0003593233,0.000132473,0.0001700528,0.00009911587,0.0001807897,0.0004985273,0.0005470057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001197508,"about_ca_system_score_gemma":0.000102004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000387519,"about_ca_topic_score_gemma":0.0002376858,"domain_scores_codex":[0.9998679,0.00001651489,0.00002018782,0.00003118514,0.00004741056,0.00001682877],"domain_scores_gemma":[0.9998502,0.00005076807,0.00002508209,0.00003152934,0.00001746988,0.00002500979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001976654,0.0000603359,0.002107403,0.00006164621,0.00002679712,0.003343468,0.000146645,0.001057103,0.9877747,0.0004337595,0.0002640511,0.004526392],"study_design_scores_gemma":[0.0000990995,0.00137208,0.03278048,0.00005901586,0.0001869044,0.02333676,0.0002576483,0.01905429,0.9082131,0.0005877718,0.01401684,0.00003598427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885307,0.0003217153,0.007622315,0.0001186327,0.00006197923,0.00006309267,0.001196253,0.000134486,0.001950847],"genre_scores_gemma":[0.994511,0.0002440427,0.002636754,0.00005737554,0.000009481054,0.00004864836,0.001337608,0.00002893833,0.001126106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002175061,"threshold_uncertainty_score":0.007276297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368939198438163,"score_gpt":0.3039517244791877,"score_spread":0.2602623324948061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}