{"id":"W2970267181","doi":"10.1093/cvr/cvz217","title":"Human iPSC modelling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytes","year":2019,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Instituto de Salud Carlos III; Novo Nordisk Fonden; Agència de Gestió d'Ajuts Universitaris i de Recerca; Ministerio de Economía y Competitividad; Generalitat de Catalunya; Fondazione Cariplo; Centres de Recerca de Catalunya","keywords":"Induced pluripotent stem cell; Atrial fibrillation; Medicine; Population; Pathophysiology; Mutation; Disease; Cardiac electrophysiology; Internal medicine; Cardiac arrhythmia; Neuroscience; Bioinformatics; Genetics; Biology; Electrophysiology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001665072,0.00009966949,0.001016768,0.000355265,0.00002711548,0.000001830134,0.00004518646,0.0001714821,0.000007351949],"category_scores_gemma":[0.000185471,0.00009128513,0.0009418494,0.0003878983,0.000237595,0.00005770364,0.00008243794,0.0002489824,9.121367e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004829271,"about_ca_system_score_gemma":0.0001075278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002689978,"about_ca_topic_score_gemma":0.000001496783,"domain_scores_codex":[0.9978564,0.0004405263,0.0004936621,0.0002623378,0.0007088337,0.000238274],"domain_scores_gemma":[0.9987346,0.000175454,0.0001031332,0.0004598173,0.0004778923,0.00004912517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004762478,0.00004680176,0.01947971,0.001880717,0.002756065,0.00003144925,0.001281145,0.09779453,0.8512974,0.0004087128,0.00001819829,0.0202428],"study_design_scores_gemma":[0.03411281,0.01622981,0.3244104,0.003179006,0.002390289,0.0002524477,0.00295192,0.03779205,0.5709534,0.006499152,0.0003554335,0.0008732409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936283,0.0049195,0.000314278,0.000006461805,0.0000486079,0.0008222125,0.000009725256,0.000004468633,0.0002464725],"genre_scores_gemma":[0.9992578,0.0004323978,0.00009976342,0.000001150608,0.0001601672,0.000005464944,0.00001756392,0.00001428451,0.00001142722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3049307,"threshold_uncertainty_score":0.37225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368939198438163,"score_gpt":0.3039517244791877,"score_spread":0.2602623324948061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}