{"id":"W2970273168","doi":"10.1016/j.ddmod.2019.08.007","title":"Gut microbes as a therapeutic armory","year":2018,"lang":"en","type":"article","venue":"Drug Discovery Today Disease Models","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Institute for Advanced Research","funders":"Technion-Israel Institute of Technology; Ministry of Science and Technology, Israel; German-Israeli Foundation for Scientific Research and Development; Glycemic Index Foundation; Canadian Institute for Advanced Research; Henry and Marilyn Taub Foundation; Seerave Foundation; Johnson and Johnson; Israel Science Foundation; Israel Cancer Research Fund","keywords":"Fecal bacteriotherapy; Biology; Microbiome; Gut flora; Disease; Colonisation resistance; Clostridium difficile; Colonization; Host (biology); Dysbiosis; Gut bacteria; Host factors; Gut microbiome; Intensive care medicine; Microbiology; Medicine; Bioinformatics; Immunology; Ecology; Antibiotics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002107387,0.0003879736,0.000433558,0.000233346,0.0002567132,0.0001863793,0.0003145133,0.00009192836,0.0008758238],"category_scores_gemma":[0.00007603055,0.0003258582,0.0003877614,0.0003823765,0.000458845,0.0004992897,0.000209266,0.0003200703,0.00105852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001957707,"about_ca_system_score_gemma":0.0009170857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000165017,"about_ca_topic_score_gemma":0.00001368258,"domain_scores_codex":[0.9971557,0.00009476555,0.0003885222,0.0007517391,0.0008136561,0.0007955824],"domain_scores_gemma":[0.9978227,0.00008466875,0.0000716536,0.001008378,0.000248386,0.0007641899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03048011,0.01360705,0.009896847,0.002264852,0.002836011,0.003525457,0.006623661,0.001769553,0.6639565,0.05981597,0.1535396,0.05168437],"study_design_scores_gemma":[0.0300101,0.004155063,0.04492487,0.003758609,0.005382509,0.0005528369,0.006001175,0.1072288,0.541441,0.112673,0.1362025,0.007669518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974086,0.003378758,0.0006133038,0.003369781,0.0002440012,0.0007316575,0.0001646154,0.0001680642,0.01724382],"genre_scores_gemma":[0.9758066,0.0004196407,0.00004053747,0.002283879,0.0008844719,0.00008598696,0.0001395129,0.0000855019,0.02025389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1225155,"threshold_uncertainty_score":0.9999194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02772328109549444,"score_gpt":0.3006078005725784,"score_spread":0.272884519477084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}