{"id":"W2970275262","doi":"10.1038/s41380-019-0477-2","title":"White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group","year":2019,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":373,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; Instituto de Salud Carlos III; National Health and Medical Research Council; Rivierduinen; University of California, San Francisco; GGZ inGeest; National Institutes of Health; Vrije Universiteit Amsterdam; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Centro de Investigación Biomédica en Red de Salud Mental; National Alliance for Research on Schizophrenia and Depression; ZonMw; Medical Research Council; Leids Universitair Medisch Centrum; Universiteit Leiden; Universitair Medisch Centrum Groningen; University of Minnesota; Science Foundation Ireland; American Foundation for Suicide Prevention; European Commission; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; European Regional Development Fund; National Healthcare Group; Rappaport Foundation; Brain and Behavior Research Foundation","keywords":"Fractional anisotropy; Major depressive disorder; Corpus callosum; White matter; Psychology; Diffusion MRI; Depression (economics); Neuroimaging; Psychiatry; Clinical psychology; Internal medicine; Medicine; Neuroscience; Magnetic resonance imaging; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001350935,0.0001528895,0.0002513315,0.000168989,0.00004900305,0.00004437858,0.000294383,0.00005205951,0.00007659282],"category_scores_gemma":[0.000007701501,0.0001201715,0.0001410307,0.0008872399,0.0000460724,0.00005867131,0.00007501428,0.0003144547,0.00001676476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003408188,"about_ca_system_score_gemma":0.00001299265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006678823,"about_ca_topic_score_gemma":0.000359521,"domain_scores_codex":[0.9987993,0.0000540154,0.0002786742,0.0004126068,0.0002138973,0.0002414637],"domain_scores_gemma":[0.9993078,0.0000245301,0.0001112046,0.0004993422,0.00002502472,0.00003216233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004817834,0.0001938596,0.9977525,0.00001462083,0.0000765352,0.00003407387,0.0001435592,0.0002443361,0.0004050593,0.0004182442,0.000383334,0.0002857104],"study_design_scores_gemma":[0.001070602,0.00002667543,0.9925027,0.0001023098,0.0001061744,0.00002608492,0.0002185655,0.001156006,0.00005785972,0.001440277,0.003135876,0.0001568279],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9618977,0.0006845129,0.02129726,0.0131106,0.0001523277,0.0006875063,0.0000162392,0.00005289594,0.002101003],"genre_scores_gemma":[0.9931863,0.00002305017,0.003491904,0.00273076,0.00003220304,0.0001924509,0.0001322685,0.00002239926,0.0001886619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03128864,"threshold_uncertainty_score":0.4900453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009484764895849637,"score_gpt":0.3067051679151785,"score_spread":0.2972204030193288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}