{"id":"W2970333537","doi":"10.1016/j.omto.2019.08.003","title":"Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Yamaguchi University; University of Michigan","keywords":"Oncolytic virus; Cancer research; Combination therapy; Melanoma; Virotherapy; Cell culture; Cancer; Virology; Biology; Medicine; Virus; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001170384,0.0002818631,0.0003592962,0.0003420325,0.0001070689,0.0002532107,0.0001864832,0.0001875111,0.0008266604],"category_scores_gemma":[0.00007339581,0.00009493544,0.0002356904,0.0001329518,0.0001085888,0.0002049103,0.0001548807,0.0003897151,0.0001541097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349489,"about_ca_system_score_gemma":0.0001741424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006853522,"about_ca_topic_score_gemma":0.002074106,"domain_scores_codex":[0.9999149,0.00001491011,0.000005959542,0.00001710921,0.00002343484,0.00002362732],"domain_scores_gemma":[0.9999676,0.000005949974,0.000008052711,0.000003657306,0.000004011888,0.00001060012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002751937,0.0001365055,0.0002793219,0.00006164151,0.00001199205,0.00004746074,0.0000187372,0.0003107676,0.9942836,0.00007049214,0.0000637059,0.004440602],"study_design_scores_gemma":[0.00003970343,0.003043312,0.002707487,0.000005827374,0.00004242699,0.0002727722,0.00001953335,0.001086704,0.9895986,0.00002918891,0.003147713,0.000006535493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960454,0.001793503,0.0008068816,0.00003948761,0.00001870207,0.00003828117,0.0001009133,0.00002999539,0.001126795],"genre_scores_gemma":[0.9962243,0.001091218,0.00120719,0.00001720001,0.000006269744,0.0000189513,0.0001985306,0.000007310853,0.001229094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008266604,"threshold_uncertainty_score":0.002765417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212262100882672,"score_gpt":0.2768667207527858,"score_spread":0.2647440997439591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}