{"id":"W2970333537","doi":"10.1016/j.omto.2019.08.003","title":"Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"Ministry of Education, Culture, Sports, Science and Technology; Japan Society for the Promotion of Science; Yamaguchi University; University of Michigan","keywords":"Oncolytic virus; Cancer research; Combination therapy; Melanoma; Virotherapy; Cell culture; Cancer; Virology; Biology; Medicine; Virus; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004148489,0.0002603235,0.0002411797,0.0001060701,0.00006652703,0.00006288819,0.0001810781,0.0001880265,0.00001863772],"category_scores_gemma":[0.00001358496,0.0002279125,0.00003809724,0.0001930899,0.00009354723,0.0000133953,0.00005636721,0.0001659526,0.000007379326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005382881,"about_ca_system_score_gemma":0.0001460773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001054339,"about_ca_topic_score_gemma":0.0002394177,"domain_scores_codex":[0.9983291,0.0001652551,0.0002436668,0.0006701871,0.0002802283,0.0003115398],"domain_scores_gemma":[0.9989579,0.00002510328,0.0001217925,0.0006792452,0.0001140701,0.0001018448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00284728,0.0002154545,0.008022415,0.00001643568,0.00004824154,0.00001062841,0.0001487182,0.00004766332,0.9758803,0.0000536743,0.00001966451,0.01268957],"study_design_scores_gemma":[0.004639103,0.008515366,0.004110215,0.00002115005,0.000005590767,0.00001298779,0.00004495522,0.0002957452,0.9779053,0.0001113584,0.004036743,0.0003014818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924059,0.005652298,0.0002051765,0.0002224734,0.00003808035,0.0009643494,0.00001016555,0.00001701951,0.0004845188],"genre_scores_gemma":[0.9903339,0.007800658,0.00045737,0.0006239607,0.00004802813,0.00008293507,0.00007299948,0.00006193594,0.0005182003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01238809,"threshold_uncertainty_score":0.9294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212262100882672,"score_gpt":0.2768667207527858,"score_spread":0.2647440997439591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}