{"id":"W2970402865","doi":"10.1371/journal.pgen.1008352","title":"Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout","year":2019,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Hôpital du Sacré-Cœur de Montréal; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Krembil Foundation; Novo Nordisk Fonden; Parkinson Society Canada; Canadian Institutes of Health Research; Parkinson Canada; Lundbeckfonden; Fondation Brain Canada","keywords":"Pars compacta; Substantia nigra; Biology; Dopamine; Neuroscience; Axon; Basal ganglia; Ventral tegmental area; Internal medicine; Cell biology; Endocrinology; Central nervous system; Dopaminergic; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000161296,0.0005143032,0.0005318553,0.00047722,0.0002235408,0.0005361729,0.000328233,0.0005772835,0.001874204],"category_scores_gemma":[0.0001409198,0.0003128624,0.0004321791,0.0001980826,0.0003357002,0.0003350226,0.0003647376,0.0009343428,0.0004195977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004281015,"about_ca_system_score_gemma":0.0002242237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001290797,"about_ca_topic_score_gemma":0.001831672,"domain_scores_codex":[0.9997066,0.0000226026,0.00003605872,0.00009091811,0.00007787288,0.00006590751],"domain_scores_gemma":[0.9996824,0.00003765254,0.00009103295,0.00002834478,0.00002678424,0.0001336941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007443935,0.00002022591,0.000167018,0.00002124802,0.000008429386,0.00006711362,0.00002034907,0.00003652808,0.9991724,0.00005022381,0.00001909101,0.0003429727],"study_design_scores_gemma":[0.00003786052,0.0005775028,0.01408923,0.00001856065,0.00006503852,0.0007484097,0.0001042406,0.001550917,0.9809191,0.00007523778,0.001798243,0.00001567118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962471,0.0006434903,0.001702674,0.00006507181,0.00002480285,0.00002264368,0.0004802238,0.00009088015,0.0007231601],"genre_scores_gemma":[0.9924781,0.000823683,0.002219121,0.00006510872,0.0000111172,0.00007640745,0.0006211962,0.00008394582,0.003621174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001874204,"threshold_uncertainty_score":0.006269872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01742353365581316,"score_gpt":0.2511905995024786,"score_spread":0.2337670658466654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}