{"id":"W2970454553","doi":"10.1016/j.stem.2019.08.002","title":"Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development","year":2019,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Neural dynamics and brain function","field":"Neuroscience","cited_by":958,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Kavli Institute for Brain and Mind, University of California, San Diego; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; University of California, San Diego; National Alliance for Research on Schizophrenia and Depression; National Institute of Mental Health; Whitehall Foundation; Foundation for the National Institutes of Health; Spectrum Pharmaceuticals; Simons Foundation Autism Research Initiative; School of Medicine, University of California, San Diego; California Institute for Regenerative Medicine; National Institutes of Health; National Science Foundation","keywords":"Organoid; Biology; Brain development; Human brain; Neuroscience; Brain waves; Electroencephalography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000137848,0.0003329945,0.0001559702,0.0002565733,0.000117688,0.0003221759,0.0003141452,0.0004104743,0.001667398],"category_scores_gemma":[0.0005768308,0.0002129385,0.000295725,0.0002025019,0.000421367,0.0003895712,0.0002555584,0.0004987415,0.0003079961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000346798,"about_ca_system_score_gemma":0.0002725451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00205442,"about_ca_topic_score_gemma":0.002200245,"domain_scores_codex":[0.999946,0.000014165,0.000002429779,0.00001496376,0.00001407642,0.000008434432],"domain_scores_gemma":[0.9997953,0.0001085145,0.00003266968,0.0000202698,0.00002019881,0.00002315167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004159696,0.00008878609,0.004427169,0.000209542,0.00006606774,0.001540454,0.0008727074,0.2783198,0.6495904,0.03787607,0.00173316,0.02485994],"study_design_scores_gemma":[0.00005236897,0.0002239751,0.008551187,0.00002389657,0.00004747364,0.0007777787,0.0003873862,0.8599844,0.1042056,0.02144249,0.004263421,0.00004009598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6205297,0.0003279094,0.3720362,0.0002021311,0.00007533009,0.00009381304,0.0007616208,0.0003476876,0.005625552],"genre_scores_gemma":[0.9727135,0.0002522894,0.02397781,0.00002194173,0.000008671889,0.00008204279,0.0002135974,0.00006458148,0.002665621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205442,"threshold_uncertainty_score":0.005578041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03181238095951786,"score_gpt":0.2301761974344977,"score_spread":0.1983638164749798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}