{"id":"W2970512064","doi":"10.1002/ijc.32657","title":"Plasma clearance of<i>RAS</i>mutation under therapeutic pressure is a rare event in metastatic colorectal cancer","year":2019,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"College of Natural Resources and Sciences, Humboldt State University; Institut National Du Cancer; CNIB; Centre National de la Recherche Scientifique; Servier; Ministère de l'Enseignement Supérieur et de la Recherche; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Digital polymerase chain reaction; Colorectal cancer; Mutation; Cancer research; Methylation; Medicine; Somatic evolution in cancer; Internal medicine; Cancer; Oncology; Polymerase chain reaction; Biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001085772,0.0000933481,0.000165582,0.00007840725,0.000008428386,0.00001741659,0.000225562,0.00004978573,0.0002298244],"category_scores_gemma":[0.00002049575,0.00008533848,0.0001076187,0.00005807921,0.00002949632,0.00001201223,0.0000360313,0.00009824545,0.000002364256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007272413,"about_ca_system_score_gemma":0.0003447508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001765342,"about_ca_topic_score_gemma":0.0003821742,"domain_scores_codex":[0.9991159,0.00002786053,0.0003416649,0.0001270077,0.0002839443,0.0001035612],"domain_scores_gemma":[0.9991195,0.00003220003,0.0003534296,0.00007199575,0.0003890921,0.00003385001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004871508,0.0003672648,0.119593,0.0001059902,0.003018057,0.000030841,0.0009946624,0.3977906,0.4143932,0.0009021119,0.002725733,0.05520707],"study_design_scores_gemma":[0.009436325,0.00101776,0.2405418,0.0006902636,0.0003435213,0.0001306286,0.0004447789,0.004897729,0.6672232,0.001497127,0.07324588,0.0005310106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823776,0.01501078,0.0003449148,0.0008135231,0.001099562,0.0001187748,0.0001443312,9.552238e-7,0.00008954296],"genre_scores_gemma":[0.9950882,0.003762237,0.0000917066,0.0006506862,0.0002324079,0.00001310942,0.000008069228,0.00001414023,0.0001394442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3928928,"threshold_uncertainty_score":0.3480002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008511880313972342,"score_gpt":0.3037570660481505,"score_spread":0.2952451857341782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}