{"id":"W2970557530","doi":"10.1038/s41467-019-11753-1","title":"The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; University of California, San Francisco; Ministero dello Sviluppo Economico; Research Councils UK; Ontario Ministry of Economic Development and Innovation; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Institute of General Medical Sciences; Diamond Light Source; British Heart Foundation; Wellcome Trust; Merck KGaA; Innovative Medicines Initiative; Wellcome; Pfizer; Engineering and Physical Sciences Research Council; Eli Lilly and Company","keywords":"Phospholipid scramblase; Endoplasmic reticulum; Cell biology; Chemistry; Lipid bilayer; Biochemistry; Biophysics; Biology; Phospholipid; Membrane; Phosphatidylserine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002393593,0.00009847203,0.00009611885,0.00007133403,0.0003554227,0.0000725382,0.001052802,0.00006869429,0.000006358174],"category_scores_gemma":[0.001534248,0.00006075202,0.00003558169,0.0004670384,0.0002867499,0.0001119885,0.0002440945,0.000588586,0.000004773987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001655568,"about_ca_system_score_gemma":0.00004578423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000130082,"about_ca_topic_score_gemma":0.0001395922,"domain_scores_codex":[0.9985965,0.0006421125,0.0002016191,0.0001920681,0.0002289257,0.0001387042],"domain_scores_gemma":[0.9963406,0.002064607,0.0001295599,0.001361458,0.00007887483,0.00002483919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004797484,0.0001028444,0.03287545,0.00001900874,0.000007006006,5.833318e-7,0.00111926,0.0002005856,0.8583152,0.1048866,0.0003819535,0.002043539],"study_design_scores_gemma":[0.0004895563,0.00006914393,0.1622329,0.00003498674,0.00001758317,0.00001363249,0.0009049517,0.006095755,0.8251619,0.001528844,0.003299637,0.0001511152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910352,0.0005619432,0.000003058527,0.005979976,0.0001259682,0.0004543418,0.00001976837,0.00001288449,0.001806815],"genre_scores_gemma":[0.998417,0.0004675438,0.0002594522,0.0007564191,0.00001653076,0.00003428738,0.00000657473,0.000009072645,0.00003317433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1293575,"threshold_uncertainty_score":0.273366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02509905820168346,"score_gpt":0.3028818256191107,"score_spread":0.2777827674174272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}