{"id":"W2970557530","doi":"10.1038/s41467-019-11753-1","title":"The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; University of California, San Francisco; Ministero dello Sviluppo Economico; Research Councils UK; Ontario Ministry of Economic Development and Innovation; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Institute of General Medical Sciences; Diamond Light Source; British Heart Foundation; Wellcome Trust; Merck KGaA; Innovative Medicines Initiative; Wellcome; Pfizer; Engineering and Physical Sciences Research Council; Eli Lilly and Company","keywords":"Phospholipid scramblase; Endoplasmic reticulum; Cell biology; Chemistry; Lipid bilayer; Biochemistry; Biophysics; Biology; Phospholipid; Membrane; Phosphatidylserine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001068139,0.0002799381,0.0002267483,0.00009108076,0.0002324886,0.0002369721,0.0003126558,0.0004371698,0.000504303],"category_scores_gemma":[0.0001507227,0.0001176032,0.0002661871,0.00006347102,0.000456332,0.0002633006,0.0002890917,0.0005506277,0.0003972862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002905107,"about_ca_system_score_gemma":0.000232417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004030754,"about_ca_topic_score_gemma":0.0002330449,"domain_scores_codex":[0.9999288,0.000009022534,0.0000110458,0.00001549311,0.00001933764,0.00001620405],"domain_scores_gemma":[0.9999127,0.000009767044,0.00003975807,0.00001022649,0.0000086774,0.00001874152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001372735,0.00002496947,0.0003129577,0.0000637475,0.00001054703,0.0006202666,0.00002760871,0.00137566,0.9939815,0.00176717,0.00008271448,0.001595438],"study_design_scores_gemma":[0.00005792601,0.0002768175,0.004471909,0.000019833,0.00001564976,0.001322055,0.000039331,0.006624554,0.982403,0.001073049,0.003676358,0.00001931185],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916298,0.001332548,0.004586578,0.0002536237,0.0000516953,0.00002552546,0.0001104355,0.0001352052,0.001874589],"genre_scores_gemma":[0.9971306,0.0004298309,0.001421017,0.00005591319,0.000006132842,0.00001530611,0.0001176985,0.00001787221,0.0008055764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000504303,"threshold_uncertainty_score":0.002107859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02509905820168346,"score_gpt":0.3028818256191107,"score_spread":0.2777827674174272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}