{"id":"W2970605878","doi":"10.1016/j.atherosclerosis.2019.08.012","title":"Krüppel-like factor 14 inhibits atherosclerosis via mir-27a-mediated down-regulation of lipoprotein lipase expression in vivo","year":2019,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Alberta; University of Calgary","funders":"University of South China; Natural Science Foundation of Hunan Province; National Natural Science Foundation of China","keywords":"Lipoprotein lipase; Chromatin immunoprecipitation; Proinflammatory cytokine; Endocrinology; Lipid metabolism; Internal medicine; Gene knockdown; Lipoprotein; Apolipoprotein E; Chemistry; Apolipoprotein B; Cell biology; Inflammation; Biology; Gene expression; Medicine; Cholesterol; Biochemistry; Apoptosis; Promoter; Gene; Adipose tissue","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004976314,0.000827499,0.0007007218,0.0007542828,0.0004150678,0.0007040023,0.0004896349,0.0004372542,0.00220355],"category_scores_gemma":[0.000292881,0.0004618376,0.0008232053,0.0003574339,0.0007426437,0.000345351,0.0004056213,0.002040373,0.001172705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006769181,"about_ca_system_score_gemma":0.0009035975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009774258,"about_ca_topic_score_gemma":0.001560015,"domain_scores_codex":[0.9994799,0.00008791489,0.00006775458,0.00009967536,0.0001167156,0.000147937],"domain_scores_gemma":[0.9997366,0.00003469392,0.00007257287,0.00004286367,0.00002843269,0.00008476218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001471622,0.0002038714,0.0001593319,0.00008075557,0.00003359081,0.00006211706,0.0000248062,0.0001487453,0.9944453,0.0003287468,0.0002436513,0.002797508],"study_design_scores_gemma":[0.0001054258,0.0003627465,0.001347814,0.000006329326,0.00004681723,0.00009637847,0.00003392113,0.001445914,0.9925956,0.0001397357,0.003807986,0.00001128217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973078,0.00496083,0.0115919,0.0009083668,0.0005086082,0.0001246117,0.00163231,0.001077955,0.006117356],"genre_scores_gemma":[0.9803186,0.002095444,0.007411616,0.0002665745,0.00005898946,0.0001377245,0.00145804,0.0001909433,0.008062077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00220355,"threshold_uncertainty_score":0.007371604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379939104295738,"score_gpt":0.2439614286184905,"score_spread":0.2301620375755332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}