{"id":"W2970643002","doi":"10.3390/pharmaceutics11090440","title":"Impact of GSTA1 Polymorphisms on Busulfan Oral Clearance in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation","year":2019,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Busulfan; Medicine; Hematopoietic stem cell transplantation; Transplantation; Genotype; Pharmacokinetics; Gastroenterology; Internal medicine; Population; Oncology; Area under the curve; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008703811,0.0001725058,0.0003195991,0.0002212119,0.0002345033,0.0003774959,0.0001154927,0.0001976326,0.0009113559],"category_scores_gemma":[0.001931632,0.0001141561,0.0002513904,0.0003065764,0.0002466123,0.0002182371,0.00019166,0.0003077771,0.0001730832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275238,"about_ca_system_score_gemma":0.0002473222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006368355,"about_ca_topic_score_gemma":0.0005349233,"domain_scores_codex":[0.9994187,0.000222914,0.00006253062,0.0001214268,0.0001166754,0.00005770273],"domain_scores_gemma":[0.9987062,0.0004275468,0.0005490275,0.00008658128,0.0001006314,0.0001299661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000836636,0.00006587803,0.9946292,0.00000818348,0.00004116927,0.0000874727,0.00008870651,0.00006525643,0.001420201,0.00001348404,0.00003091141,0.002712899],"study_design_scores_gemma":[0.00002335607,0.001640126,0.996186,0.000003229049,0.00005046248,0.0005955538,0.0001007973,0.000335031,0.0008749763,0.00002209206,0.0001652121,0.000003103921],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997999,0.00006884839,0.00004820618,0.000006023822,7.409861e-7,0.000002327763,0.0000229572,0.000001039982,0.00005002296],"genre_scores_gemma":[0.999862,0.00001997888,0.00003944305,0.000006300539,0.000002175444,0.000002499965,0.00004767688,6.723909e-7,0.00001934439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009113559,"threshold_uncertainty_score":0.004603028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01451611142225253,"score_gpt":0.2848349792667734,"score_spread":0.2703188678445209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}