{"id":"W2970679260","doi":"10.1016/j.tcb.2019.08.002","title":"The Nucleolus as a Proteostasis Regulator","year":2019,"lang":"en","type":"article","venue":"Trends in Cell Biology","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Azrieli Foundation","keywords":"Proteostasis; Nucleolus; Biology; Protein folding; Aggresome; Cell biology; Protein aggregation; Nucleus; Regulator; Protein degradation; Ubiquitin; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001333545,0.00008936086,0.00008473964,0.00004042953,0.00005626833,0.0000111316,0.0002200478,0.00013727,0.0002080665],"category_scores_gemma":[0.00001059468,0.0000620467,0.00005285926,0.0001182982,0.00008154288,0.000001213144,0.00006527275,0.00007294121,0.00012539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001417038,"about_ca_system_score_gemma":0.00003572997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004854942,"about_ca_topic_score_gemma":0.00007431678,"domain_scores_codex":[0.9992841,0.00005993642,0.0001392467,0.0002688458,0.00003470535,0.0002131716],"domain_scores_gemma":[0.9994274,0.00001151053,0.00005348852,0.000456214,0.00002235363,0.00002898369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001345679,0.00005523943,0.0082015,0.000004851694,0.00001956113,7.274139e-7,0.00004055574,0.00002765091,0.8426511,0.00223361,0.003393083,0.1432376],"study_design_scores_gemma":[0.0006074819,0.0003503395,0.0073387,0.000002829079,0.000004540029,0.000003771102,0.00007113915,0.00005078536,0.1475029,0.0004247937,0.8434835,0.0001592425],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9482056,0.001318034,0.0000123583,0.0005088312,0.0001912595,0.0001199052,0.000008497094,0.000007167918,0.04962831],"genre_scores_gemma":[0.9802148,0.0002777435,0.0001007215,0.0001569973,0.00007303466,0.00005822977,0.00005654854,0.00001099759,0.01905097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8400904,"threshold_uncertainty_score":0.2530191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008697189605360055,"score_gpt":0.2718881501234491,"score_spread":0.263190960518089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}