{"id":"W2970683697","doi":"10.1016/j.ebiom.2019.08.041","title":"Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease","year":2019,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Nierstichting","keywords":"Metformin; Medicine; Canagliflozin; AMPK; Internal medicine; Kidney disease; Endocrinology; Pharmacology; Kidney; Renal function; Sitagliptin; Diabetes mellitus; Type 2 diabetes; Protein kinase A; Biology; Kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005585061,0.0009262789,0.001035426,0.001203137,0.0002986279,0.0005082602,0.0008532697,0.001091241,0.002400414],"category_scores_gemma":[0.000200329,0.000436166,0.001190041,0.0004155629,0.0007419943,0.0006877889,0.0003325339,0.002172118,0.0005804747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005832465,"about_ca_system_score_gemma":0.0007569379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101787,"about_ca_topic_score_gemma":0.002595302,"domain_scores_codex":[0.9994293,0.00006085081,0.00008066422,0.0001364022,0.0001872033,0.0001055445],"domain_scores_gemma":[0.999363,0.00004653012,0.0002501512,0.00004732005,0.00004817271,0.0002448235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001580684,0.000421716,0.0003277842,0.0001409031,0.00003451392,0.00007833051,0.00002464177,0.0001553597,0.9950184,0.00008649898,0.0001936843,0.001937477],"study_design_scores_gemma":[0.0003514404,0.004590231,0.004388103,0.00003253277,0.0001120959,0.0003336403,0.00006218011,0.001769073,0.9857431,0.00008178598,0.002515288,0.00002041818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875351,0.002746468,0.003917837,0.0008332446,0.0002617425,0.000172193,0.00207119,0.0006255214,0.001836665],"genre_scores_gemma":[0.9802657,0.002842625,0.006768426,0.0004679074,0.00007136154,0.0003322398,0.001971049,0.0001409325,0.007139688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002400414,"threshold_uncertainty_score":0.008030236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009587524307120765,"score_gpt":0.2457744883927567,"score_spread":0.236186964085636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}