{"id":"W2970797613","doi":"10.1007/s00213-019-05350-9","title":"Upregulation of antioxidant thioredoxin by antidepressants fluoxetine and venlafaxine","year":2019,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Health Sciences Centre","funders":"Brain and Behavior Research Foundation","keywords":"Venlafaxine; Fluoxetine; Downregulation and upregulation; Pharmacology; Thioredoxin; Psychology; Medicine; Psychiatry; Antidepressant; Chemistry; Oxidative stress; Internal medicine; Serotonin; Anxiety; Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001477842,0.0001348409,0.0001990418,0.00004168266,0.00003098187,0.000003535624,0.0001315312,0.0001760632,0.0001854628],"category_scores_gemma":[0.0000182919,0.0001228763,0.00004404911,0.00006573065,0.0001672301,0.000005074793,0.00007278485,0.00008492432,0.00001454236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002768777,"about_ca_system_score_gemma":0.00001398326,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000570232,"about_ca_topic_score_gemma":0.000001440211,"domain_scores_codex":[0.9990687,0.000113039,0.0002170903,0.0003526157,0.00006024469,0.0001883434],"domain_scores_gemma":[0.9995412,0.00002276012,0.0001325327,0.0001922604,0.00005877543,0.00005245034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004639088,0.00007065387,0.0751447,0.00002485214,0.00007115865,8.846105e-7,0.00001657341,0.000009605116,0.9181706,0.00005565452,0.004336478,0.00163494],"study_design_scores_gemma":[0.002328347,0.0004106215,0.1625982,0.00001064209,0.00002269739,0.00001480424,0.0000178013,0.00004828589,0.8190746,0.00009792641,0.01522014,0.0001559634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953858,0.002248759,0.0002010218,0.0001635599,0.0004183316,0.0002388345,0.00005294188,0.000008645266,0.001282091],"genre_scores_gemma":[0.997789,0.0008676123,0.0002107059,0.000226421,0.00008703901,0.0000107358,0.0001012493,0.00001330392,0.0006939733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09909603,"threshold_uncertainty_score":0.501075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003147679367264197,"score_gpt":0.2623465474549745,"score_spread":0.2591988680877104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}