{"id":"W2970812924","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4405","title":"HIV-Nef Protein Persists in Bronchoalveolar Lavage Derived Extracellular Vesicles of HIV Patients on ART and Induces EMAPII Amplified Endothelial Cell Apoptosis Resulting in Pulmonary Vascular Pathologies Like Pulmonary Hypertension","year":2019,"lang":"en","type":"article","venue":"","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Bronchoalveolar lavage; Apoptosis; Pulmonary hypertension; Extracellular vesicles; Medicine; Extracellular; Human immunodeficiency virus (HIV); Cell; Lung; Immunology; Chemistry; Cell biology; Biology; Cardiology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521296,0.0001288614,0.0001629493,0.0002392649,0.0003171461,0.0005256447,0.0001687015,0.0003850236,0.001771103],"category_scores_gemma":[0.0004301618,0.0001239009,0.000178774,0.0001221357,0.0001762263,0.0002180345,0.0002888991,0.0005274533,0.0002619032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000165825,"about_ca_system_score_gemma":0.000150942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006768554,"about_ca_topic_score_gemma":0.0006003741,"domain_scores_codex":[0.9998389,0.00003315052,0.00001298084,0.00003118726,0.00003792463,0.00004574113],"domain_scores_gemma":[0.9999049,0.00002268297,0.00002379924,0.00001044559,0.0000178015,0.00002041791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002494859,0.0002638279,0.08222148,0.0001909213,0.0001581818,0.003153474,0.0004681085,0.000193319,0.8902388,0.0005322359,0.0007198048,0.01936498],"study_design_scores_gemma":[0.0001412512,0.001160012,0.5829315,0.00009464221,0.0001892475,0.01096049,0.001820294,0.004183406,0.3914026,0.0007217878,0.006355026,0.0000397467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997793,0.0008821674,0.0004347351,0.00007620044,0.00002804346,0.00001323586,0.0002647129,0.000009360714,0.0004985749],"genre_scores_gemma":[0.9983341,0.000209208,0.0002566121,0.00005857272,0.00001189323,0.00001260157,0.0003501126,0.000002379579,0.0007645799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001771103,"threshold_uncertainty_score":0.005924881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01899814687931929,"score_gpt":0.2299501774381104,"score_spread":0.2109520305587911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}