{"id":"W2970828832","doi":"10.1016/j.freeradbiomed.2019.08.032","title":"Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial","year":2019,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Edible Oils Quality and Analysis","field":"Chemistry","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"H2020 Marie Skłodowska-Curie Actions; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Generalitat de Catalunya","keywords":"Hydroxytyrosol; Simvastatin; Pharmacology; Tyrosol; PON1; CYP2A6; Internal medicine; Crossover study; Medicine; Endocrinology; Cytochrome P450; Chemistry; Biochemistry; Placebo; CYP3A4; Genotype; Polyphenol; Metabolism; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0018399,0.001801733,0.004233362,0.0004051999,0.000580558,0.001308775,0.0008144955,0.002945289,0.007344964],"category_scores_gemma":[0.002264012,0.0008039679,0.003050424,0.0005088669,0.001426263,0.001157302,0.00044324,0.003478722,0.0007469007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005835137,"about_ca_system_score_gemma":0.0008300332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085954,"about_ca_topic_score_gemma":0.001453009,"domain_scores_codex":[0.9990966,0.000451952,0.00007840353,0.0001721079,0.00006366094,0.0001371926],"domain_scores_gemma":[0.9987638,0.0005469677,0.0002478956,0.0001053511,0.00008453058,0.000251485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9910408,0.001263606,0.0002414492,0.0008126904,0.001391379,0.00002373209,0.00001470141,0.00006189931,0.0008329441,0.00006388396,0.0002660223,0.003987042],"study_design_scores_gemma":[0.9688019,0.02672585,0.001128014,0.0000774787,0.002158865,0.00001989503,0.00001869191,0.0001857611,0.0002806718,0.000146629,0.0004415812,0.00001475462],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503703,0.03667483,0.001414557,0.001386634,0.002059373,0.003130075,0.001444096,0.0001617083,0.0033585],"genre_scores_gemma":[0.9776162,0.01122785,0.001234797,0.001572868,0.00144919,0.002630696,0.0009668003,0.00003301382,0.003268672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007344964,"threshold_uncertainty_score":0.02457136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01641451022052414,"score_gpt":0.2534469642661062,"score_spread":0.237032454045582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}