{"id":"W2970852343","doi":"10.1002/cmdc.201900466","title":"Single Amino Acid Replacement in G‐7039 Leads to a 70‐fold Increase in Binding toward GHS‐R1a","year":2019,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; Thunder Bay Regional Research Institute; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; G protein-coupled receptor; Receptor; Secretagogue; Internal medicine; Stereochemistry; Endocrinology; Molecular biology; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001648067,0.0004296332,0.0002947328,0.0001538717,0.0001258891,0.0002248792,0.0003145003,0.0003950839,0.002585927],"category_scores_gemma":[0.0001969107,0.000132877,0.0002754143,0.0001723111,0.0002476719,0.0001270472,0.0002328382,0.0004609619,0.0006983817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003330605,"about_ca_system_score_gemma":0.0003001934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143208,"about_ca_topic_score_gemma":0.0009499713,"domain_scores_codex":[0.9998343,0.00002506835,0.00001982903,0.00002490408,0.00003539897,0.00006047136],"domain_scores_gemma":[0.9998815,0.00002567315,0.0000295738,0.000009759001,0.000007436182,0.0000461043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004761849,0.0001243371,0.0001126531,0.00002823729,0.00001534395,0.0003742104,0.00001641598,0.0003928258,0.9968624,0.0001465256,0.0001125517,0.001338394],"study_design_scores_gemma":[0.0001150977,0.0012376,0.001606684,0.000009610138,0.00002810507,0.0006729126,0.00002923614,0.001594923,0.9915015,0.00004427338,0.003145192,0.00001479918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972078,0.0003368347,0.0006354322,0.00009595412,0.00006793119,0.00002983796,0.0002714742,0.00008062951,0.001274174],"genre_scores_gemma":[0.9970489,0.000298649,0.0009509029,0.00007830531,0.00001103552,0.00001525473,0.0003207026,0.00003201225,0.001244251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002585927,"threshold_uncertainty_score":0.00865078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701090912255469,"score_gpt":0.2445688645050408,"score_spread":0.2275579553824861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}