{"id":"W2970852343","doi":"10.1002/cmdc.201900466","title":"Single Amino Acid Replacement in G‐7039 Leads to a 70‐fold Increase in Binding toward GHS‐R1a","year":2019,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University; Thunder Bay Regional Research Institute; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; G protein-coupled receptor; Receptor; Secretagogue; Internal medicine; Stereochemistry; Endocrinology; Molecular biology; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004087176,0.00022684,0.0002679441,0.0001380456,0.00002200514,0.00003317968,0.0002483756,0.0002152523,0.0003282329],"category_scores_gemma":[0.0001119202,0.0002351088,0.00008405415,0.0002415496,0.00001894484,0.000007909061,0.000214303,0.0001530102,0.000123343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000127771,"about_ca_system_score_gemma":0.00005982501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006580155,"about_ca_topic_score_gemma":0.00005398435,"domain_scores_codex":[0.9983782,0.00003775252,0.0003422864,0.000588887,0.0001837088,0.0004691298],"domain_scores_gemma":[0.9993135,0.0000129762,0.00007439169,0.0004108914,0.00003514898,0.0001530679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001638923,0.0001184754,0.007624723,0.00004003582,0.00001058812,0.000008962743,0.0002579217,0.00002375966,0.9900888,0.0000301734,0.0006083263,0.001024307],"study_design_scores_gemma":[0.001025937,0.0003247138,0.000262745,0.00008633466,0.000004814184,0.000006077643,0.0003360079,0.00005676014,0.9924268,0.00002659576,0.005143191,0.000300001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959368,0.0002329891,0.0001774061,0.0001949695,0.0001972882,0.0003656119,0.000006538707,0.00001517834,0.002873288],"genre_scores_gemma":[0.9967733,0.00002543914,0.001034091,0.0004920965,0.0001264953,0.0000571818,0.00009481869,0.00003668676,0.001359871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007361978,"threshold_uncertainty_score":0.9587457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701090912255469,"score_gpt":0.2445688645050408,"score_spread":0.2275579553824861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}