{"id":"W2970966292","doi":"10.14785/lymphosign-2019-0011","title":"New considerations in hematopoietic stem cell transplantation for severe combined immunodeficiency: how did newborn screening change our field, and can we finally brake the glass ceiling for haploidentical transplantation?","year":2019,"lang":"en","type":"article","venue":"LymphoSign Journal","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Transplantation; Hematopoietic stem cell transplantation; Severe combined immunodeficiency; Stem cell; Newborn screening; Disease; Intensive care medicine; Immunology; Pediatrics; Surgery; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004856543,0.0002349408,0.0003256915,0.0001210621,0.0007117969,0.0001766593,0.000217677,0.0002019282,0.00003215499],"category_scores_gemma":[0.00002082614,0.0001913283,0.000163893,0.0001245813,0.00004535637,0.0002800413,0.00001358235,0.0003053661,0.000005595079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003649484,"about_ca_system_score_gemma":0.0002350731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000108631,"about_ca_topic_score_gemma":0.00006063775,"domain_scores_codex":[0.9985723,0.0001405986,0.0004596349,0.000274805,0.00006989493,0.0004827216],"domain_scores_gemma":[0.998898,0.0006323982,0.0002042752,0.0001600739,0.00008562907,0.00001965183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007236064,0.0008731827,0.01149316,0.001965062,0.0006808247,0.00006758102,0.1457934,0.001912158,0.5955805,0.01666163,0.001837862,0.2158985],"study_design_scores_gemma":[0.2168367,0.01194559,0.111935,0.006883986,0.003748624,0.02496562,0.2075045,0.01092107,0.3254062,0.05016214,0.02258793,0.007102631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7202179,0.02496926,0.2319655,0.0189366,0.001449575,0.002221789,0.0001207741,0.00005317575,0.00006543341],"genre_scores_gemma":[0.9968649,0.0009654255,0.0009321406,0.0004901342,0.0000172,0.00007516493,0.00006787287,0.00002510835,0.0005620968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.276647,"threshold_uncertainty_score":0.7802141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01832097053543886,"score_gpt":0.2336855244946848,"score_spread":0.215364553959246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}